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Pretvorbe karbonilnih spojin pri klasičnih pogojih
ID Podkoritnik, Andrej (Author), ID Jereb, Marjan (Mentor) More about this mentor... This link opens in a new window

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Abstract
V diplomskem delu sem podrobno testiral nekatere klasične sintezne smeri za pretvorbo karbonilnih spojin ter z njimi pripravil 37 produktov z visoko dodano vrednostjo. S klasično in moderno sintezo Friedel–Craftsovega aciliranja sem pripravil arilne ketone z dobrimi do odličnimi izkoristki. Pri tem sem analiziral vpliv aktiviranosti aromatskega obroča substrata na aciliranje aromatov. S katalitično reakcijo in brez uporabe topila sem iz kislinskih kloridov ter metanola sintetiziral metilne estre. Ti so služili kot prekurzorji za Kulinkovichevo reakcijo sinteze ciklopropanolov. Reakcije sem najprej vodil v manjšem merilu in le uspešne izvedel na večji skali. Prav vpliv merila je odigral občutno vlogo na potek reakcij.

Language:Slovenian
Keywords:karbonilne spojine, Friedel–Craftsovo aciliranje, Kulinkovicheva reakcija, katalitične pretvorbe
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2020
PID:20.500.12556/RUL-120784 This link opens in a new window
COBISS.SI-ID:35151107 This link opens in a new window
Publication date in RUL:25.09.2020
Views:1204
Downloads:173
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Secondary language

Language:English
Title:Transformation of carbonyl compounds under classic conditions
Abstract:
In the thesis I tested in detail the reactivity of some classical synthesis reactions for the conversion of carbonyl compounds and used them to prepare 37 products with high added value. With the classical and modern synthesis of Friedel–Crafts acylation, I prepared aryl ketones with good to excellent yields. I analyzed the influence of the aromatic ring activation of the substrate on the acylation of the aromatic compounds. With a catalytic reaction and without the use of a solvent, I synthesized methyl esters from acid chlorides and methanol. Methyl esters served as precursors for the Kulinkovich synthesis reaction of cyclopropanols. I first conducted the reactions on a smaller scale and only carried out the successful ones on a larger scale. Scale played a significant role on the reactivity of the reactions.

Keywords:Friedel–Crafts acylation, carbonyl compounds, Kulinkovich reaction, catalytic transformations

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