Diabetes mellitus poses a great challenge to society, as current therapies do not eliminate the root cause of the disease, i.e. pancreatic beta cell dysfunction. The product of many years of development of new compounds are numerous zinc complexes. They have already been tested and were confirmed to have anti-diabetic properties, but due to their toxicity they are not yet suitable for the treatment of diabetes mellitus.
Masters’s thesis includes synthesis of amide derivatives of dipicolinic acid and analysis of protone specters. The synthesis of dipicolinic acid amide analogs consists of multistep reaction. The starting product is dimethyl ester of dipicolinic acid. In the first step the ester is hydrolysed to methyl ester of dipicolinic acid via basic hydrolysis with KOH. The next step is synthesis of the acid chloride under inert conditions on the Schlenk line followed by the conversion of the acid chloride into amide derivative with the selected amine. The last step is basic haydrolisis of ester group to carboxyl group. The resulting products are amide derivatives of dipicolinic acid, which are suitable for the synthesis of coordination zinc compounds.
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