Sistematični pregled izsledkov raziskav o antioksidativnih lastnostih fluvastatina : Bachelor Study Programme Cosmetology

Šilc, Tina (author), Černe, Darko (mentor)

Ozadje: Fluvastatin je zaviralec 3-hidroksi-3-metilglutaril-koencim A (HMG-CoA) reduktaze. Ima številne ugodne učinke na žilno steno, ki so neodvisni od zniževanja holesterola LDL in jih imenujemo pleiotropni učinki. Med pleiotropne učinke sodi tudi zaviranje intracelularnega (pa tudi vaskularnega) oksidacijskega stresa. Namen: Pregledati literaturo in izdelati sistematični pregled raziskav ter tako ugotoviti, ali literatura dokazuje, da ima fluvastatin antioksidativne lastnosti. Metode: Z uporabo vnaprej določenega iskalnega profila smo v podatkovni bazi PubMed poiskali raziskave, objavljene do konca aprila 2018. Iskalni profil, ki smo ga določili, je bil sledeč: fluvastatin[Text Word] AND (antioxidant[Text Word] OR antioxidative[Text Word]). Vključili smo raziskave, ki so vrednotile antioksidativne lastnosti fluvastatina. S pregledom literature v relevantnih raziskavah smo pridobili dodatno raziskavo, ki smo jo vključili v sistematični pregled. Rezultati: V sistematičnem pregledu smo obravnavali 8 raziskav, ki so ustrezale vključitvenim in izključitvenim kriterijem. Glede na objavljeno literaturo smo prišli do zaključka, da imajo fluvastatin in njegovi metaboliti antioksidativne lastnosti, ki izhajajo neposredno iz njihove strukture in niso povezane z osnovnim delovanjem fluvastatina kot zaviralca HMG-CoA reduktaze.

• Language: Slovenian
• Keywords: fluvastatin, zaviralec 3-hidroksi-3-metilglutaril-koencim A (HMG-CoA), reduktaze, antioksidativne lastnosti, odstranjevalec radikalov
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FFA - Faculty of Pharmacy
• Place of publishing: Ljubljana
• Publisher: [T. Šilc]
• Year: 2018
• Number of pages: V, 28 f.
• PID: 20.500.12556/RUL-120143
• UDC: 615.272:547.922(043.2)
• COBISS.SI-ID: 4569969
• Publication date in RUL: 16.09.2020

Secondary language

• Language: English
• Title: Systematic review of results of studies evaluating antioxidative properties of fluvastatin : Bachelor Study Programme Cosmetology

Abstract

Background: Fluvastatin is a 3-hydroxy-3-methylglutaryl (HMG-CoA) reductase inhibitor. The inhibition of HMG-CoA reductase may produce pleiotropic effects that are independent of LDL-cholesterol lowering. Pleiotropic effects of statins include antioxidant properties among others protective effects. Aim: To review the literature relating to the antioxidative properties of fluvastatin. Methods: Using pre-defined search profile in the database PubMed we retrieved all studies on the subject published by the end of April 2018. The search profile used was: fluvastatin[Text Word] AND (antioxidant[Text Word] OR antioxidative[Text Word]). The inclusion criteria included all studies about antioxidative properties of fluvastatin. We manually searched relevant studies to retrieve one additional study. Results: 8 studies fulfilled all inclusion and exclusion criteria. Majority of studies confirmed antioxidative activity of fluvastatin. On the basis of the results, it was concluded that the antioxidative activity of fluvastatin and its metabolites is independent from the inhibition of HMG-CoA reductase.

• Keywords: fluvastatin 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor antioxidative properties statins radical scavenger