Sinteza nekaterih halkogeniranih derivatov

Šuklje, Nataša (author), Jereb, Marjan (mentor)

Halkogeni derivati so pomembne spojine. V organski kemiji lahko služijo kot intermediati v sintezi, mnoge halkogene spojine pa imajo tudi biološko delovanje. V zadnjih letih se je organska kemija selena in telurja zelo razvila. Selenov atom je lahko v organoselenove spojine vključen kot elektrofil ali nukleofil. Poznamo elektrofilne kot tudi nukleofilne selenove reagente. V diplomskem delu bom opisala nekatere metode s katerimi jih lahko sintetiziramo. Selenocianate lahko pripravimo z direktnim ali indirektnim seleniliranjem. V kemiji so uporabni kot intermediati za nadaljnje sinteze. Zaradi svojih različnih bioloških lastnosti pa se lahko uporabljajo tudi v kemoterapiji. Tako kot organoselenova, ima tudi organotelurjeva kemija široko področje za nadaljnji razvoj. Tako npr. selen in telur vsebujejo 5-arilhalkogenoalkil-1H-tetrazoli, ki imajo protiglivično delovanje.

• Language: Slovenian
• Keywords: organoselenove spojine, organotelurjeve spojine, halkogeni elementi
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2020
• PID: 20.500.12556/RUL-119402
• COBISS.SI-ID: 28691715
• Publication date in RUL: 08.09.2020

ŠUKLJE, Nataša, 2020, Sinteza nekaterih halkogeniranih derivatov [online]. Bachelor’s thesis. [Accessed 14 April 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=119402

Secondary language

• Language: English
• Title: Synthesis of some chalcogenated derivatives

Abstract

Chalcogen derivatives are important compounds. In organic chemistry they can serve as intermediates in synthesis, and many of chalcogen compounds also exhibit biological activity. In recent years, chemistry using selenium and tellurium has evolved greatly. Selenium atom can be incorporated into compounds as a nucleophile or an electrophile. Electrophilic as well as nucleophilic selenium reagents are known. In this thesis I will describe some methods by which we can synthesise them. Selenocyanates can be prepared by direct or indirect selenocyanation. In chemistry they can be used as intermediates for further synthesis. Due to their various biological properties, they can also be used in chemotherapy. Like organoselenes, organotellurium chemistry has a wide field with greater possibilities for development. For example, selenium and tellurium containing 5-arylchalcogenoalkyl-1H-tetrazoles have displayed anifungal activity.

• Keywords: organoselenium compounds, organotellurium compounds, chalcogen elements