Celična terapija za regeneracijo srca po srčni kapi

Zupančič, Ana (author), Ogorevc, Jernej (mentor)

Srčno–žilne bolezni so v razvitem delu sveta in tudi v Sloveniji že desetletja najpogostejši vzrok obolevnosti in umrljivosti odraslih. Če je ob srčnem infarktu pretok krvi prekinjen dlje kot 20-30 minut, so posledice ireverzibilne, saj srčne celice odmrejo. Naravno prisotna regenerativna sposobnost človekovega srčnega mišičnega tkiva je bistveno preslaba, da bi lahko kompenzirala obsežne izgube celic. S celično terapijo se prvič, če izvzamemo presaditve srca, lotevamo reševanja dejanskega vzroka in odpravljanja težav ne le lajšanja simptomov. Glavni namen te diplomske naloge je opis različnih celičnih tipov in njihova ustreznost za regeneracijo srca, nekaj pozornosti pa namenim nadaljnjim izzivom, ki jih bo potrebno rešiti preden bo celična terapija postala učinkovita in razširjena terapija za regeneracijo srca po srčni kapi. Za regeneracijo srca s celično terapijo so primerni različni donorski celični tipi – od somatskih matičnih (predniških) celic pa vse do induciranih pluripotentnih matičnih celic in transdiferenciranih celic. Idealnega celičnega tipa, ki bi bil primeren za vse paciente verjetno ni. Nadaljnje študije se bodo verjetno vse bolj usmerjale v uporabo programiranih celic ter čedalje manj v uporabo alogenih (matičnih) celic. Poleg ustreznega izbora donorskih celic je za višjo učinkovitost celične terapije potrebno izboljšati metode vnosa celic, njihovo preživetje in vraščanje v tkivo.

• Language: Slovenian
• Keywords: srčni infarkt, regeneracija srca, celična terapija, matične celice
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Publisher: [A. Zupančič]
• Year: 2020
• PID: 20.500.12556/RUL-119043
• UDC: 602.9:611.018:606:616.127-005.8(043.2)
• COBISS.SI-ID: 27482627
• Publication date in RUL: 02.09.2020

ZUPANČIČ, Ana, 2020, Celična terapija za regeneracijo srca po srčni kapi [online]. Bachelor’s thesis. A. Zupančič. [Accessed 14 April 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=119043

Secondary language

• Language: English
• Title: Cell therapy for heart regeneration after heart infarction

Abstract

Cardiovascular diseases have been the most common cause of morbidity and mortality in adults in the developed part of the world and in Slovenia for decades. If the blood flow is interrupted for more than 20-30 minutes during a heart attack, the consequences are irreversible, as the heart cells die. The naturally present regenerative capacity of human cardiac muscle tissue is too weak to be able to compensate for extensive tissue loss. Cell therapy enables for the first time, with the exception of heart transplants, we to tackle and resolve the actual cause instead of just relieving symptoms. The main purpose of this thesis is to describe the different cell types and their suitability for heart regeneration, and further challenges that will need to be addressed before heart regeneration cell therapy becomes effective and widespread therapy for heart regeneration after heart attack. Various donor cell types are suitable for heart regeneration with cell therapy - from somatic stem (progenitor) cells, to induced pluripotent stem cells and transdifferentiated cells. There is probably no ideal cell type that would be suitable for all patients. Further studies are likely to focus more on the use of programmed cells. In addition to the suitable selection of donor cells, the methods of cell delivery, cell survival, and tissue growth need to be improved to increase the effectiveness of heart regeneration cell therapy.

• Keywords: heart infarction, heart regeneration, cell therapy, stem cells