Could sex/gender differences in ACE2 expression in the lungs contribute to the large gender disparity in the morbidity and mortality of patients infected with the SARS-CoV-2 virus?

Majdič, Gregor (avtor)

COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). Although there are no data for the lung, the expressions of RAS components in other tissues are modulated by sex hormones, androgens, and estrogens. However, there are no data on sex-specific differences in ACE2 expression. If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients.

• Jezik: Angleški jezik
• Ključne besede: pneumonia viral, corona virus infection, epidemiology, peptidyl-dipeptidase A, androgens, estrogens, blood, sex factors, sex distribution, COVID-19
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.03 - Drugi znanstveni članki
• Organizacija: VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 3 str.
• Številčenje: Vol. 10, art. 327
• PID: 20.500.12556/RUL-118708
• UDK: 616.24:616.9
• ISSN pri članku: 2235-2988
• DOI: 10.3389/fcimb.2020.00327
• COBISS.SI-ID: 20234499
• Datum objave v RUL: 31.08.2020

Gradivo je del revije

• Naslov: Frontiers in cellular and infection microbiology
• Skrajšan naslov: Front. cell. infect. microbiol.
• Založnik: Frontiers Media
• ISSN: 2235-2988
• COBISS.SI-ID: 523093785

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 31.08.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: virusna pljučnica, corona virusna infekcija, epidemiologija, peptidil-dipeptidaza A, androgeni, estrogeni, kri, spolni faktorji, porazdelitev spolov, COVID-19

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0053
• Naslov: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih