The master thesis describes ruthenium catalyzed direct C–H arylation of 3-heteroarylisoquinolines, followed by palladium catalyzed direct C–H arylation. We successfully optimized the reaction conditions of both steps to achieve the optimum conversion. Several different monoarylated and some diarylated products were synthesized using the optimized conditions. We further used the optimized conditions to perform a sequential one-pot reaction for the synthesis of the final diarylated products. We were interested in whether the sequential one-pot method was as effective as if the reactions was performed sequentially with purification of the intermediate. By comparing the yields of the products, we concluded that both modes of synthesis of diarylated products are similarly effective.
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