Obolevnost prebivalcev Slovenije za akutnim koronarnim sindromom v povezavi z nekaterimi meteorološkimi spremenljivkami : doktorska disertacija

Ravljen, Mirjam (author), Bilban, Marjan (mentor), Kajfež-Bogataj, Lučka (co-mentor)

Akutni koronarni sindrom (AKS) je posledica zapore koronarne arterije s krvnim strdkom. Predstavlja glavni vzrok umiranja okoli 1,8 milijona ljudi v Evropi. K razvoju obolenja pripomorejo številni dejavniki tveganja. Mnoge raziskave povezujejo pojav obolenja z vremenom, pri nas problem še ni raziskan. V ta namen smo analizirali povezanost med povprečno dnevno temperaturo, vlažnostjo in zračnim tlakom na dan obravnave in v razponu 7 dni pred obravnavo ter številom urgentno obravnavanih pacientov z AKS v obdobju od 1. 1. 2008 do 31. 12. 2011 v intervencijskih katetrskih laboratorijih v Sloveniji. Uporabili smo Poissonov regresijski model, v katerega je bila kot kontrolna spremenljivka vključena tudi sezona. Pokazalo se je, da so z incidenco obravnavanih pacientov negativno povezani povprečna dnevna temperatura na dan obravnave in vsaj 7 dni pred tem, vlažnost do 2 dni in z zamikom 5 do 7 dni ter zračni tlak v obdobju do 4 dni pred tem. Pri pacientih, starejših od 65 let, je z incidenco negativno povezana le temperatura. Izsledki so primerljivi z rezultati podobnih raziskav, izvedenih v Evropi. Pri pacientih, mlajših od 65 let, sta negativno povezani vlažnost in zračni tlak. Tujih raziskav, ki bi analizirale vpliv slednjih, je malo, njihovi izsledki so kontradiktorni ter patofiziološki mehanizem nepojasnjen.

• Language: Slovenian
• Keywords: vreme, temperatura, vlažnost, obolevnost prebivalcev, koronarna srčna bolezen, meteorološke spremenljivke, Slovenija, akutni koronarni sindrom
• Work type: Dissertation
• Typology: 2.08 - Doctoral Dissertation
• Organization: BF - Biotechnical Faculty
• Place of publishing: Ljubljana
• Publisher: [M. Ravljen]
• Year: 2016
• Number of pages: XI, 106, [14] f.
• PID: 20.500.12556/RUL-115369
• UDC: 616.12:551.58(497.4)(043.3)=163.6
• URN: URN:NBN:SI:doc-5E0FW20Y
• COBISS.SI-ID: 8502137
• Publication date in RUL: 24.04.2020

Secondary language

• Language: English
• Title: Acute coronary syndrome morbidity of the population of Slovenia in relation to some meteorological variables

Abstract

Acute Coronary Syndrome (ACS) is as a result of a sudden reduction of blood flow to part of the heart caused by a blood clot. It represents the main cause of dying of approximately 1.8 million people in Europe. Many researches associate the appearance of diseases with the weather. In Slovenia the problem has not been studied yet. The correlation between an average daily temperature, humidity and barometric pressure as well as the incidence of ACS, within the period of 1st January 2008 until 31st January 2011 was analyzed by means of Poisson regression analysis. The results have shown the incidence of all treated patients to be negatively correlated with average daytime temperature on the same day as well as all week before, humidity up to two days as well as 5 to 7 days and air pressure up to four days before. In patients, older than 65 years it turned out that, only temperature is negatively correlated with the occurrence of diseases. These findings are comparable to research results from most European countries. The incidence of the disease in patients, younger than 65 years, is negatively correlated with humidity and barometric pressure. The number of researches that have analyzed these impact is low, the results are contradictory and pathophysiological mechanism remains unclear.

• Keywords: weather, temperature, humidity, morbidity of population, coronary heart disease, meteorological variables, Slovenia, acute coronary syndrome