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Phenotypes associated with pathogenicity : their expression in Arctic fungal isolates
ID
Perini, Laura
(
Author
),
ID
Mogrovejo, Diana C.
(
Author
),
ID
Tomazin, Rok
(
Author
),
ID
Gostinčar, Cene
(
Author
),
ID
Brill, Florian H. H.
(
Author
),
ID
Gunde-Cimerman, Nina
(
Author
)
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https://www.mdpi.com/2076-2607/7/12/600
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Abstract
Around 85% of the environments on Earth are permanently or seasonally colder than 5 °C. Among those, the poles constitute unique biomes, which harbor a broad variety of microbial life, including an abundance of fungi. Many fungi have an outstanding ability to withstand extreme conditions and play vital ecosystem roles of decomposers as well as obligate or facultative symbionts of many other organisms. Due to their dispersal capabilities, microorganisms from cryosphere samples can be distributed around the world. Such dispersal involves both species with undefined pathogenicity and potentially pathogenic strains. Here we describe the isolation of fungal species from pristine Arctic locations in Greenland and Svalbard and the testing of the expression of characteristics usually associated with pathogenic species, such as growth at 37 °C, hemolytic ability, and susceptibility to antifungal agents. A total of 320 fungal isolates were obtained, and 24 of the most abundant and representative species were further analyzed. Species known as emerging pathogens, like Aureobasidium melanogenum, Naganishia albida, and Rhodotorula mucilaginosa, were able to grow at 37 °C, showed beta-hemolytic activity, and were intrinsically resistant to commonly used antifungals such as azoles and echinocandins. Antifungal resistance screening revealed a low susceptibility to voriconazole in N. albida and Penicillium spp. and to fluconazole in Glaciozyma watsonii and Glaciozyma-related taxon.
Language:
English
Keywords:
Arctic
,
fungi
,
emerging pathogens
,
thermotolerance
,
hemolysis
,
antifungal resistance
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
BF - Biotechnical Faculty
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2019
Number of pages:
15 str.
Numbering:
Vol. 7, iss. 12, art. 600
PID:
20.500.12556/RUL-113479
UDC:
579
ISSN on article:
2076-2607
DOI:
10.3390/microorganisms7120600
COBISS.SI-ID:
5275471
Publication date in RUL:
10.01.2020
Views:
1357
Downloads:
393
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Record is a part of a journal
Title:
Microorganisms
Shortened title:
Microorganisms
Publisher:
MDPI AG
ISSN:
2076-2607
COBISS.SI-ID:
523277081
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.12.2019
Projects
Funder:
EC - European Commission
Funding programme:
H2020
Project number:
675546
Name:
Microorganisms in Warming Arctic Environments
Acronym:
MicroArctic
Funder:
ARRS - Slovenian Research Agency
Project number:
I0-0021
Name:
Infrastrukturni center za raziskave molekulskih interakcij, Razvojno raziskovalni center za proučevanje rasti in razvoja kmetijskih rastlin, IC Mycosmo
Funder:
ARRS - Slovenian Research Agency
Project number:
I0-0022
Name:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0170
Name:
Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0198
Name:
Molekularno-biološke raziskave mikroorganizmov
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