Aktuacijski sklop peristaltičnega simulatorja

Juriševič, Anja (author), Diaci, Janez (mentor)

Z namenom odprave pomanjkljivosti, ki so se izkazale tekom izvajanja in-vitro testov sproščanja farmakoloških učinkovin s pomočjo peristaltičnega simulatorja, je bil razvit nov tip kontraktorja za izvajanje krožnih kontrakcij, ki omogoča silo stiska 12 N in velikost odprtine zaslonke od 10-45 mm. V okviru te magistrske naloge smo na podlagi zahtev in specifikacij koncipirali in razvili nov mehanizem zaslonke, ga prototipirali, ter na osnovi preračunov in izboljšav modela izdelali testno verzijo kontraktorja. Izdelali smo tudi testno napravo, s katero smo testirali zasnovani kontraktor in preverili, da pravilno deluje in omogoča stiskanje fleksibilne vreče s silo več kot 1 N v vseh pogojih delovanja. Na podlagi uspešnega preverjanja delovanja je bilo izdelanih 16 enakih kontrakcijskih mehanizmov, ki so bili vgrajeni v izboljšano verzijo peristaltičnega simulatorja s povečano zmogljivostjo.

• Language: Slovenian
• Keywords: testiranje, sproščanja učinkovin, peristaltika, kontrakcije, mehanske zaslonke, snovanje kontraktorja
• Work type: Master's thesis/paper
• Typology: 2.09 - Master's Thesis
• Organization: FS - Faculty of Mechanical Engineering
• Place of publishing: Ljubljana
• Publisher: [A. Juriševič]
• Year: 2019
• Number of pages: XXV, 88 str.
• PID: 20.500.12556/RUL-112574
• UDC: 004.383.4:621.337(043.2)
• COBISS.SI-ID: 16958235
• Publication date in RUL: 25.10.2019

Secondary language

• Language: English
• Title: Actuation assembly of the peristaltic simulator

Abstract

In order to remedy the shortcomings revealed during the in-vitro tests of pharmacological agents release using a peristaltic simulator, a new type of contractor for performing circular contractions has been developed. The constriction mechanism allows a compression force of 12 N and an aperture size of 10-45 mm. In the context of this master's thesis, we designed and developed a new aperture mechanism based on the given requirements and specifications. Furthermore, we prototyped the new concept and based on the calculations and model improvements, made a test version of the contractor. We also designed a test device with which we tested the assembled constriction mechanism to verify that it works properly and allows to squeeze a flexible bag with the required force of at least 1 N in all operating conditions. Based on the successful performance checks, 16 identical contraction mechanisms were built and incorporated into an improved version of the new peristaltic simulator with increased capacity.

• Keywords: substance release, testing, peristalsis, contractions, mechanical shutters, constriction mechanism design