Prototip scintilacijskega detektorja za merjenje uhajanja pri izolirani perfuziji udov

CVENKEL, DOMEN (author), Trost, Andrej (mentor), Pestotnik, Rok (comentor)

Pri rakavih bolnikih z melanomom ali sarkomom, omejenim na en ud, se kot alternativa amputaciji ali drugim operacijam izvaja kirurški poseg, imenovan izolirana perfuzija udov. Pacientovo okončino pri tem priklopijo na izoliran krvni obtok in vanj dodajo tekočino, ki med drugim vsebuje radioaktivno snov ter visoke odmerke zdravil. Med posegom je potrebno ves čas spremljati, da uhajanje tekočine iz izolirane okončine v preostali del telesa ne preseže dovoljene meje, saj bi v nasprotnem primeru to predstavljajo nevarnost za pacienta. V magistrski nalogi je predstavljen prototip prenosnega scintilacijskega detektorja za merjenje radioaktivnosti, ki se uporablja za zaznavanje uhajanja. Detektor je v grobem sestavljen iz scintilatorja, fotopomnoževalke, večkanalnega analizatorja in grafičnega uporabniškega vmesnika. Kot večkanalni analizator smo uporabili FPGA vezje na razvojni plošči Red Pitaya. Motiv za delo je sestaviti detektor, ki je majhen in lahko prenosen in bi v prihodnosti lahko zamenjal obstoječ detektor na Onkološki kliniki UKC Ljubljana.

• Language: Slovenian
• Keywords: izolirana perfuzija udov, radioaktivnost, uhajanje, scintilator, fotopomnoˇzevalka, FPGA, Red Pitaya
• Work type: Master's thesis/paper
• Organization: FE - Faculty of Electrical Engineering
• Year: 2019
• PID: 20.500.12556/RUL-110683
• Publication date in RUL: 18.09.2019

Secondary language

• Language: English
• Title: Prototype scintillation detector for leakage measurement during isolated limb perfusion

Abstract

Isolated limb perfusion is a surgical procedure used for treating cancer patients with melanoma or sarcoma isolated to a single limb. It is used as an alternative to limb amputation or other mutilating operations. Patient’s limb is disconnected from systemic bloodstream and connected to its own isolated one in which radioactive tracer and high dosage of medication are injected. During procedure, constant monitoring of fluid leakage from isolated limb to systemic bloodstream is important for patient’s safety. In case leakage exceeds safe threshold, the procedure is stopped. Thesis addresses a portable prototype scintillation detector for measuring radioactivity which indirectly measures leakage during isolated limb perfusion. Detector is based on scintillator, photomultiplier, multichannel analyzer and graphic user interface. Multichannel analyzer is made with FPGA circuit on Red Pitaya development board. The main motive for work was to build a small and portable detector which could in future replace the one that is currently used at the Institute of Oncology in Ljubljana.

• Keywords: isolated limb perfusion, radioactivity, leakage, scintillator, photomultiplier, Red Pitaya, FPGA