Kvasovka Saccharomyces cerevisiae kot modelni organizem za preučevanje procesov staranja.

Fuks, Alen (author), Jamnik, Polona (mentor)

Diplomsko delo obsega predstavitev rezultatov določenih raziskav staranja na kvasovki kot modelnem organizmu. Zaradi vse večjega deleža starega prebivalstva, postaja staranje tema, ki se vedno bolj raziskuje z namenom kakovostnejšega in daljšega življenja. Na staranje lahko vplivamo z genetskim spreminjanjem, kot je utišanje ali delecija genov, tretiranjem s kemijskimi spojinami ter s spremembo prehrane, kjer vsi načini vplivajo na poti, ki zaznavajo dostopnost hranil. V prvem delu diplomskega dela je predstavljeno, zakaj je kvasovka lahko primerni model za študij procesov staranja, nato sta razložena replikativno (RLS) in kronološko staranje (CLS). Za tem sledi razlaga procesov, ki se dogajajo preko RLS in CLS v odvisnosti od aktiviranja/deaktiviranja poti, ki zaznavajo dostopnost hranil.

• Language: Slovenian
• Keywords: staranje, poti zaznavanja hranil, biotehnologija, RLS, CLS
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Publisher: [A. Fuks]
• Year: 2019
• PID: 20.500.12556/RUL-110396
• UDC: 601.4:582.282.23:57.017.6(043.2)
• COBISS.SI-ID: 9363321
• Publication date in RUL: 14.09.2019

FUKS, Alen, 2019, Kvasovka Saccharomyces cerevisiae kot modelni organizem za preučevanje procesov staranja. [online]. Bachelor’s thesis. A. Fuks. [Accessed 15 April 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=110396

Secondary language

• Language: English
• Title: Yeast Saccharomyces cerevisiae as a model organism for the study of aging processes.

Abstract

This thesis consists of presenting the results of certain studies of yeast aging as a model organism. Due to the increasing share of the old population, aging is becoming a topic, which is being increasingly explored for the purpose of a better and longer life. Aging can be influenced by genetic modifications, such as shutting off genes or gene deletion, treatment with chemical compounds and with a change in diet, where all modes affect pathways, that sense nutrient availability. The first part of the thesis presents why yeast can be a suitable model for the study of aging processes and then replicative (RLS) and chronological (CLS) aging are explained. This is followed by an explanation of the processes that occur through RLS and CLS, depending on the activaton/deactivation of pathways that detect nutrient availability.

• Keywords: aging, nutrient detection pathways, biotechnology, RLS, CLS