Uporaba nanomaterialov za nevroprotektivnost.

Krklec, Daniel (author), Drobne, Damjana (mentor)

S staranjem prebivalstva postajajo nevrodegenerativne bolezni vse pogostejši pojav v moderni družbi, saj je pogostost pojava bolezni veliko večja pri starejših. Trenutno še ne poznamo ustreznih metod zdravljenja, saj ne moremo priti z zdravili v možgane. Predvidevajo, da bi v naslednjem stoletju, če ne najdemo zdravila lahko nevrodegenerativne bolezni dohitele rak po številu smrti starostnikov. Eden od kandidatov za zdravila so zaradi svoje majhnosti nanodelci. Lahko bi jih uporabili za prečkanje krvno-možganske pregrade ali pa jih uporabili kot nosilce in bi z njihovo pomočjo prenesli zdravila v prizadete dele. Nanomateriali predstavljajo širok spekter različnih snovi. Zaradi tega je tudi njihovo delovanje možno na več načinov. Lahko delujejo kot antioksidanti, kot zaviralci nadaljnjega razvoja bolezni ali pa kot snovi, ki bolezensko stanje pozdravijo. Kot pomemben antioksidant je izpostavljen cerijev oksid, ki zaradi svojih regenerativnih sposobnosti zahteva le eno doziranje. Raziskovalci so že dobili številne pozitivne rezultate s testiranji na modelnih organizmih in tkivnih kulturah. Trenutno pa so nadaljnje raziskave na ljudeh omejene, saj še ne poznamo najbolje možnih strupenih učinkov nanodelcev na človeško telo. Vseeno pa ob ustreznih doziranjih še ni bilo opaženih akutnih strupenih učinkov in zato nanodelci predstavljajo velik up, da postanejo prve zdravilne učinkovine, ki bi delovale proti nevrodegenerativnim boleznim.

• Language: Slovenian
• Keywords: nanodelci, nevrodegenerativne bolezni, terapija, nanomedicina, cerijev oksid
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Publisher: [D. Krklec]
• Year: 2019
• PID: 20.500.12556/RUL-110393
• UDC: 606:61:620.3(043.2)
• COBISS.SI-ID: 9363577
• Publication date in RUL: 14.09.2019

Secondary language

• Language: English
• Title: The use of nanomaterials for neuroprotectivity

Abstract

The human population is geting older on average and because of this the prevalence of neurodegenerative diseases is getting higher. Currently there is no known available for this type of disase. This is mainly caused by the fact that we can not enter the brain with potential therapeutics. Both facts lead to predictions that neurodegenerative diseases might overtake cancer as the leading reason of elderly death. Nanoparticles are a candidate to become the cure for this because of their small size. We could use them to cross the blood brain barrier themselves or to carry other therapeutics across. Nanomaterials represent a big specter of different substances so their potential usage is different. They can be used as antioxidants, as disease inhibitors or as a cure for the disease. Cherium oxide is highlighted as the most important nanoparticle antioxidant so far because it only requires one dosage as the particles possess the ability of regeneration. Researchers have already aquired numerous positive results with tests on model organisms and tissue cultures. Currently there are no researches taking place on humans as there is still a lot unknown about the potential toxic effect on the particles on human bodies. Nonetheless there are no known records of acute toxicity if the right dose of nanoparticles is being used so they represent a big hope of becoming the first therapeutics for neurodegenerative diseases.

• Keywords: nanoparticles, neurodegenerative diseases, therapy, nanomedicine, cherium oxide