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Vrednotenje superoksid dismutazne aktivnosti izbranih spojin z aminskimi in nitroksidnimi skupinami
ID Barovič, Darja (Author), ID Mravljak, Janez (Mentor) More about this mentor... This link opens in a new window

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Abstract
Radikali so izrazito reaktivne snovi, ki imajo v svoji strukturi vsaj en nesparjen elektron. V telesu nastajajo v fiziološki presnovi celice, pri sintezi hormonov in nevrotransmiterjev ter za obrambo organizma pred patogeni. Ob povečanem nastajanju in zmanjšanem odstranjevanju radikalov, pa lahko pride do radikalsko sproženih oksidacij, kar vodi do nastanka oksidativnega stresa. Celice v telesu se pred oksidativnim stresom zavarujejo z antioksidativnim sistemom, ki deluje zaščitno in zdravilno. Enega od zaščitnih mehanizmov celic predstavlja encimski antioksidant superoksid dismutaza, ki odstranjuje superoksidni anion (superoksid). Pomembnost superoksid dismutaze je vzrok za razvoj encimomimetikov - antioksidantov, ki posnemajo delovanje tega encima.

Language:Slovenian
Keywords:oksidativni stres, SOD-mimetik, superoksid dismutaza, superoksid, nitroksid
Work type:Master's thesis/paper
Organization:FFA - Faculty of Pharmacy
Year:2019
PID:20.500.12556/RUL-108327 This link opens in a new window
Publication date in RUL:28.06.2019
Views:1072
Downloads:219
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Secondary language

Language:English
Title:Evaluation of superoxide dismutase activity of selected compounds with amine and nitroxide groups
Abstract:
Free radicals are highly reactive substances with a structure characterised by at least one unpaired electron. They are used within the body for the physiological metabolism of cells, the synthesis of hormones and neurotransmitters and as a defence against pathogens. Increased production of radicals can, however, lead to radical-induced oxidation and, consequently, to oxidative stress. Cells are protected from oxidative stress by the antioxidant system, which has preventive and curative function. One of the mechanisms for protecting cells is the enzymatic antioxidant superoxide dismutase which removes the superoxide anion. The importance of the superoxide dismutase has led to the development of enzyme mimetics – antioxidants which mimic the activities of this enzyme.

Keywords:oxidative stress, mimetic SOD, superoxide dismutase, superoxide anion, nitroxide

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