Izdelava cepiv.

Popelar, Urban (author), Narat, Mojca (mentor)

Cepljenje predstavlja pomemben preventivni ukrep proti boleznim. Cepiva delujejo na različne načine, različni pa so tudi postopki izdelave. Izdelava je kritičen postopek, saj je potrebno zagotoviti ustrezne pogoje, na koncu pa dobiti cepivo, ki bo uspešno ščitilo proti boleznim in ne imelo stranskih učinkov. V cepivih lahko uporabijo žive, a oslabljene ali pa inaktivirane mikroorganizme. Imunost lahko sprožijo s konjugiranimi proteini, polisaharidi, toksoidi ali pa očiščenimi deli mikroorganizmov. Poseben način izdelave predstavlja rekombinantno cepivo. Pri tem pridobijo antigene s pomočjo ekspresijskih sistemov. Novejši pristopi, ki ji bom opisal v tem delu, obsegajo DNK in RNK cepiva. Postopki izdelav so nekoliko drugačni od »tradicionalnih« cepiv, prav tako pa tudi delovanje cepiv. Veliko raziskav poteka na temo DNK in RNK cepiv, saj so do sedaj pokazale veliko obetov.

• Language: Slovenian
• Keywords: cepiva, izdelava cepiv, vrste cepiv, tehnologije izdelave cepiv, genska cepiva
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Publisher: [U. Popelar]
• Year: 2018
• PID: 20.500.12556/RUL-102936
• UDC: 615.371:606:628(043.2)
• COBISS.SI-ID: 9057401
• Publication date in RUL: 12.09.2018

POPELAR, Urban, 2018, Izdelava cepiv. [online]. Bachelor’s thesis. U. Popelar. [Accessed 14 April 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=102936

Secondary language

• Language: English
• Title: Vaccine manufacturing.

Abstract

Vaccinations play an important role in preventing diseases. Vaccines work differently and manufacturing also differs from vaccine to vaccine. Manufacturing is a critical step, as certain conditions need to be fullfilled for the vaccines to successfully protect from diseases. Live, but attenuated, or inactivated microorganisms can be used in vaccines. Immunity can be triggered by conjugated proteins, polysaccharides, toxoids or subunits. Recombinant vaccines require a special kind of manufacturing. Antigens are produced with help of expression systems. Newer approaches include DNA and RNA vaccines, which will be mentioned later in this degree. Production and ways of providing immunity differ from conventional vaccines. There is a lot of ongoing research on the topic of DNA and RNA vaccines, as the early stages showed great promise.

• Keywords: vaccines, vaccine manufacturing, vaccine types, technologies for vaccine manufacturing, gene vaccines