1. Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cellsJerneja Kladnik, James P. C. Coverdale, Jakob Kljun, Hilke Burmeister, Petra Lippman, Francesca G. Ellis, Alan M. Jones, Ingo Ott, Isolda Romero-Canelón, Iztok Turel, 2021, original scientific article Keywords: ruthenium, pyrithione, resistance to chemotherapy, cancer, ovarian, thioredoxin Full text (file, 3,10 MB) This document has more files! More... |
2. Binding kinetics of ruthenium pyrithione chemotherapeutic candidates to human serum proteins studied by HPLC-ICP-MSKatarina Marković, Radmila Milačič, Stefan Marković, Jerneja Kladnik, Iztok Turel, Janez Ščančar, 2020, original scientific article Keywords: ruthenium-based chemotherapeutics, drug candidates, pyrithione, kinetics study, human serum, speciation analysis, CLC monolithic chromatography, CIM Protein G, DEAE disks, UV spectrometry, isotope dilution inductively coupled plasma mass spectrometry Full text (file, 2,80 MB) This document has more files! More... |
3. Structural isomerism and enhanced lipophilicity of pyrithione ligands of organoruthenium(II) complexes increase inhibition on AChE and BuChEJerneja Kladnik, Samuel Ristovski, Jakob Kljun, Andrea Defant, Ines Mancini, Kristina Sepčić, Iztok Turel, 2020, original scientific article Keywords: Alzheimer’s disease, acetylcholinesterase, butyrylcholinesterase, cholinesterase inhibitor, molecular docking, organoruthenium(II) complexes, pyrithione derivatives Full text (file, 1,28 MB) This document has more files! More... |
4. Fine tuning of cholinesterase and glutathione-S-transferase activities by organoruthenium(II) complexesTomaž Trobec, Kristina Sepčić, Monika C. Žužek, Jerneja Kladnik, Nina Podjed, Catarina Cardoso Páscoa, Iztok Turel, Robert Frangež, 2021, original scientific article Keywords: cholinesterase, enzyme inhibition, glutathione S-transferase, organoruthenium complex, pyrithione, β-diketone, carbonyl, glutathione transferase Full text (file, 751,83 KB) This document has more files! More... |
5. Zinc pyrithione is a potent inhibitor of PL$^{Pro}$ and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replicationJerneja Kladnik, Ana Dolinar, Jakob Kljun, David Perea, Judith Grau-Expósito, Meritxell Genescà, Marko Novinec, Maria J. Buzon, Iztok Turel, 2022, original scientific article Keywords: antiviral agents, SARS-CoV-2, inhibition, pyrithione, zinc Full text (file, 1,91 MB) This document has more files! More... |