51. Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitorsSjors van Klaveren, Jaka Dernovšek, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf Nilsson, Tihomir Tomašič, 2022, original scientific article Full text (file, 1010,75 KB) This document has more files! More... |
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55. Discovery of desmuramylpeptide NOD2 agonists with single-digit nanomolar potencySamo Guzelj, Špela Bizjak, Žiga Jakopin, 2022, original scientific article Keywords: NOD2, desmuramylpeptide, immunostimulant, adamantane, PBMC cytotoxicity, K562, agonists, cells, peptides and proteins, reaction products, toxicological synergy Full text (file, 2,68 MB) This document has more files! More... |
56. Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activitySamo Guzelj, Sanja Nabergoj, Martina Gobec, Stane Pajk, Veronika Weiss, Bram Slütter, Ruža Frkanec, Adela Štimac, Primož Šket, Janez Plavec, Irena Mlinarič-Raščan, Žiga Jakopin, 2021, original scientific article Keywords: reaction products, peptides, proteins, cells, organic compounds, toxicity Full text (file, 7,19 MB) This document has more files! More... |
57. Structure-guided design of D-galactal derivatives with high affinity and selectivity for the galectin-8 n-terminal domainMujtaba Hassan, Floriane Baussière, Samo Guzelj, Anders Sundin, Maria Håkansson, Rebeka Kovačič, Hakon Leffler, Tihomir Tomašič, Marko Anderluh, Žiga Jakopin, 2021, original scientific article Keywords: Galectin-8N, d-galactal, benzimidazole, selectivity, X-ray crystallography, cytokine secretion Full text (file, 3,43 MB) This document has more files! More... |
58. Benzimidazole-galactosides bind selectively to the galectin-8 N-terminal domainMujtaba Hassan, Sjors van Klaveren, Maria Håkansson, Carl Diehl, Rebeka Kovačič, Floriane Baussière, Anders Sundin, Jaka Dernovšek, Marko Anderluh, Tihomir Tomašič, Žiga Jakopin, 2021, original scientific article Keywords: benzimidazole, galectin-8N, quinoline, selectivity, molecular dynamics, x-ray crystallography Full text (file, 1,71 MB) This document has more files! More... |
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60. Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiatorsSamo Guzelj, Matjaž Weiss, Bram Slütter, Ruža Frkanec, Žiga Jakopin, 2022, original scientific article Keywords: immunostimulatory activity, vaccines, immune responses, pattern recognition receptors, synthesis of NOD2 agonist, Toll-like receptor 7 Full text (file, 4,87 MB) This document has more files! More... |