|
92. Polyfunctionalized α-phenyl-tert-butyl(benzyl)nitronesDaniel Diez-Iriepa, Damijan Knez, Stanislav Gobec, Isabel Iriepa, Cristóbal de los Ríos, Isaac Bravo, Francisco López-Muñoz, José Marco-Contelles, Dimitra Hadjipavlou-Litina, 2022, original scientific article Keywords: butyrylcholinesterase, free radical scavengers, neuroprotection, α-phenyl-tert-butyl(benzyl)nitrones, in vitro digestion, extractable and bound phenolics Full text (file, 2,12 MB) This document has more files! More... |
93. From tryptophan-based amides to tertiary aminesAnže Meden, Damijan Knez, Xavier Brazzolotto, Florian Nachon, Jose Dias, Jurij Svete, Jure Stojan, Uroš Grošelj, Stanislav Gobec, 2022, original scientific article Keywords: cholinesterase inhibitors, Alzheimer's disease, butyrylcholinesterase, carbamate, pseudoirreversible inhibition Full text (file, 4,55 MB) This document has more files! More... |
94. Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and BDamijan Knez, Natalia Colettis, Luca G. Iacovino, Matej Sova, Anja Pišlar, Janez Konc, Samo Lešnik, Josefina Higgs, Fabiola Kamecki, Irene Mangialavori, Ana Dolšak, Simon Žakelj, Jurij Trontelj, Janko Kos, Claudia Binda, Nora Marder Mariel, Stanislav Gobec, 2020, original scientific article Keywords: binding energy, ethyl groups, inhibition, inhibitors, molecular structure Full text (file, 6,41 MB) This document has more files! More... |
95. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warheadKatarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György Keserü M., Stanislav Gobec, 2022, original scientific article Keywords: antibacterial agents, UDP-N-acetylglucosamine enolpyruvyl transferase, thiol reactivity Full text (file, 4,05 MB) This document has more files! More... |
96. Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapyAna Mitrović, Janja Završnik, Georgy Mikhaylov, Damijan Knez, Urša Pečar Fonović, Petra Matjan-Štefin, Miha Butinar, Stanislav Gobec, Boris Turk, Janko Kos, 2022, original scientific article Keywords: cathepsin X, cathepsin B, inhibitors, cancer, antitumor therapy, invasion Full text (file, 8,24 MB) This document has more files! More... |
97. Next-generation heterocyclic electrophiles as small-molecule covalent MurA inhibitorsPéter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György Keserü M., 2022, original scientific article Keywords: covalent inhibitor, heterocyclic electrophiles, cysteine labelling, quaternization, MurA Full text (file, 1,46 MB) This document has more files! More... |
98. Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesisMatic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec, 2023, original scientific article Keywords: fragment-based drug discovery, hit triage, inhibitors, antibacterial agents Full text (file, 1,79 MB) This document has more files! More... |
99. Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities—The case of Valeriana carnosa Sm. (Caprifoliaceae) studied in miceCarolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder, 2023, original scientific article Keywords: Alzheimer’s disease, medicinal plant, acetylcholinesterase, antioxidant, β-amyloid aggregation, monoamine oxidase, memory, antidepressant Full text (file, 4,82 MB) This document has more files! More... |
100. Fragment-sized thiazoles in fragment-based drug discovery campaignsMatic Proj, Martina Hrast, Damijan Knez, Krištof Bozovičar, Katarina Grabrijan, Anže Meden, Stanislav Gobec, Rok Frlan, 2022, original scientific article Keywords: thiazoles, hit profiling, promiscuous compounds, frequent hitters, privileged scaffolds, fragments Full text (file, 2,30 MB) This document has more files! More... |