131. Synthesis, molecular modelling and biological evaluation of novel heterodimeric, multiple ligands targeting cholinesterases and amyloid betaMichalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska, 2016, izvirni znanstveni članek Ključne besede: cholinesterase inhibitors, molecular modelling, β-amyloid aggregation inhibitors, Alzheimer’s disease, multi-target-directed ligands (MTDL), PAMPA-BBB assay Celotno besedilo (datoteka, 3,87 MB) Gradivo ima več datotek! Več... |
132. Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's diseaseYoussef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili, 2016, izvirni znanstveni članek Ključne besede: Alzheimer's disease, quinazolinones, multicomponent reactions, multitarget-directed ligands, antioxidants, cholinesterase inhibitors, hepatotoxicity Celotno besedilo (datoteka, 1,47 MB) Gradivo ima več datotek! Več... |
133. Screening of big pharma’s library against various in-house biological targetsDamijan Knez, Stanislav Gobec, Martina Hrast, 2022, izvirni znanstveni članek Ključne besede: Merck Mini Library, screening, MurA, MurC, human MAO-A/B, human BChE, murine AchE Celotno besedilo (datoteka, 8,55 MB) Gradivo ima več datotek! Več... |
134. Redox active or thiol reactive?Matic Proj, Damijan Knez, Izidor Sosič, Stanislav Gobec, 2022, pregledni znanstveni članek Ključne besede: redox, covalent, screening, hits, PAINS, assays Celotno besedilo (datoteka, 1,04 MB) Gradivo ima več datotek! Več... |
135. Polyfunctionalized α-phenyl-tert-butyl(benzyl)nitronesDaniel Diez-Iriepa, Damijan Knez, Stanislav Gobec, Isabel Iriepa, Cristóbal de los Ríos, Isaac Bravo, Francisco López-Muñoz, José Marco-Contelles, Dimitra Hadjipavlou-Litina, 2022, izvirni znanstveni članek Ključne besede: butyrylcholinesterase, free radical scavengers, neuroprotection, α-phenyl-tert-butyl(benzyl)nitrones, in vitro digestion, extractable and bound phenolics Celotno besedilo (datoteka, 2,12 MB) Gradivo ima več datotek! Več... |
136. From tryptophan-based amides to tertiary aminesAnže Meden, Damijan Knez, Xavier Brazzolotto, Florian Nachon, Jose Dias, Jurij Svete, Jure Stojan, Uroš Grošelj, Stanislav Gobec, 2022, izvirni znanstveni članek Ključne besede: cholinesterase inhibitors, Alzheimer's disease, butyrylcholinesterase, carbamate, pseudoirreversible inhibition Celotno besedilo (datoteka, 4,55 MB) Gradivo ima več datotek! Več... |
137. Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and BDamijan Knez, Natalia Colettis, Luca G. Iacovino, Matej Sova, Anja Pišlar, Janez Konc, Samo Lešnik, Josefina Higgs, Fabiola Kamecki, Irene Mangialavori, Ana Dolšak, Simon Žakelj, Jurij Trontelj, Janko Kos, Claudia Binda, Nora Marder Mariel, Stanislav Gobec, 2020, izvirni znanstveni članek Ključne besede: binding energy, ethyl groups, inhibition, inhibitors, molecular structure Celotno besedilo (datoteka, 6,41 MB) Gradivo ima več datotek! Več... |
138. Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapyAna Mitrović, Janja Završnik, Georgy Mikhaylov, Damijan Knez, Urša Pečar Fonović, Petra Matjan-Štefin, Miha Butinar, Stanislav Gobec, Boris Turk, Janko Kos, 2022, izvirni znanstveni članek Ključne besede: cathepsin X, cathepsin B, inhibitors, cancer, antitumor therapy, invasion Celotno besedilo (datoteka, 8,24 MB) Gradivo ima več datotek! Več... |
139. Next-generation heterocyclic electrophiles as small-molecule covalent MurA inhibitorsPéter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György Keserü M., 2022, izvirni znanstveni članek Ključne besede: covalent inhibitor, heterocyclic electrophiles, cysteine labelling, quaternization, MurA Celotno besedilo (datoteka, 1,46 MB) Gradivo ima več datotek! Več... |
140. Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities—The case of Valeriana carnosa Sm. (Caprifoliaceae) studied in miceCarolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder, 2023, izvirni znanstveni članek Ključne besede: Alzheimer’s disease, medicinal plant, acetylcholinesterase, antioxidant, β-amyloid aggregation, monoamine oxidase, memory, antidepressant Celotno besedilo (datoteka, 4,82 MB) Gradivo ima več datotek! Več... |