1. Anthranilic acid inhibitors of undecaprenyl pyrophosphate synthase (UppS), an essential enzyme for bacterial cell wall biosynthesisMarko Jukič, Kaja Rožman, Matej Sova, Hélène Barreteau, Stanislav Gobec, 2019, original scientific article Keywords: UppS, inhibitors, cell-wall, pharmacophore model, antibacterial agents, undecaprenyl pyrophosphate synthase Full text (file, 4,42 MB) This document has more files! More... |
2. 3D pharmacophore-based discovery of novel Kv10.1 inhibitors with antiproliferative activityŽan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin-Mašič, 2021, original scientific article Keywords: K$_V$10.1, ion channels, hERG, pharmacophore modelling, virtual screening, antiproliferative activity Full text (file, 14,79 MB) This document has more files! More... |
3. Selective DNA gyrase inhibitorsTihomir Tomašič, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant, 2021, original scientific article Keywords: antibacterial, ATP-competitive, DNA gyrase, Hsp90, pharmacophore model, topoisomerase II, target activity profiling, topoisomerase IIα Full text (file, 6,96 MB) This document has more files! More... |
4. Molecular dynamics-derived pharmacophore model explaining the nonselective aspect of K$_V$10.1 pore blockersŽan Toplak, Franci Merzel, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašič, 2021, original scientific article Keywords: cancer, Eag1, hERG, K$_V$10.1 inhibitors, molecular dynamics, pharmacophore Full text (file, 10,02 MB) This document has more files! More... |
5. Novel scaffolds for modulation of NOD2 identified by pharmacophore-based virtual screeningSamo Guzelj, Tihomir Tomašič, Žiga Jakopin, 2022, original scientific article Keywords: antagonist, homology modeling, NOD2, Nucleotide-binding oligomerization, pharmacophore modeling, virtual screening Full text (file, 24,71 MB) This document has more files! More... |