11. THP-1 cells and pro-inflammatory cytokine productionŽiga Jakopin, Emanuela Corsini, 2019, original scientific article Keywords: THP-1, cytokines, IL-8, TNF-α, immunomodulation, NOD1 antagonist, NOD2 antagonist, functional characterization Full text (file, 2,22 MB) This document has more files! More... |
12. Iskanje modulatorjev programirane smrti celic kronične limfocitne levkemijeSanja Nabergoj, 2021, doctoral dissertation Keywords: receptor EP4, prostaglandinski receptorji, receptor NOD2, modelna celična linija MEC-1, protitumorno delovanje, terapija bolnikov, kronična limfocitna levkemija Full text (file, 5,74 MB) |
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14. Novel scaffolds for modulation of NOD2 identified by pharmacophore-based virtual screeningSamo Guzelj, Tihomir Tomašič, Žiga Jakopin, 2022, original scientific article Keywords: antagonist, homology modeling, NOD2, Nucleotide-binding oligomerization, pharmacophore modeling, virtual screening Full text (file, 24,71 MB) This document has more files! More... |
15. Development of novel NOD2 agonists and dual NOD2 and TLR7 agonists as vaccine adjuvantsSamo Guzelj, 2022, doctoral dissertation Keywords: conjugates, desmuramylpeptides, immune synergy, immunomodulation, NOD2, pattern recognition receptors, TLR7, vaccine adjuvants Full text (file, 23,63 MB) |
16. Discovery of desmuramylpeptide NOD2 agonists with single-digit nanomolar potencySamo Guzelj, Špela Bizjak, Žiga Jakopin, 2022, original scientific article Keywords: NOD2, desmuramylpeptide, immunostimulant, adamantane, PBMC cytotoxicity, K562, agonists, cells, peptides and proteins, reaction products, toxicological synergy Full text (file, 2,68 MB) This document has more files! More... |
17. Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiatorsSamo Guzelj, Matjaž Weiss, Bram Slütter, Ruža Frkanec, Žiga Jakopin, 2022, original scientific article Keywords: immunostimulatory activity, vaccines, immune responses, pattern recognition receptors, synthesis of NOD2 agonist, Toll-like receptor 7 Full text (file, 4,87 MB) This document has more files! More... |
18. Lipidation of NOD2 agonists with adamantane and stearoyl moieties differentially regulates their In vivo adjuvant activitySamo Guzelj, Marcela Šišić, Špela Bizjak, Leo Frkanec, Ruža Frkanec, Žiga Jakopin, 2022, original scientific article Keywords: NOD2 agonist, vaccine adjuvant, adamantane, immunopotentiators, desmuramylpeptides Full text (file, 980,38 KB) This document has more files! More... |