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12. Application of the N-dibenzyl protective group in the preparation of β-lactam pseudopeptidesRok Frlan, Martina Hrast, Stanislav Gobec, 2019, original scientific article Keywords: β-lactams, dibenzylamino, Mitsunobu reaction, nocardicin, pseudopeptides Full text (file, 1,55 MB) This document has more files! More... |
13. Computational design and development of benzodioxane-benzamides as potent inhibitors of FtsZ by exploring the hydrophobic subpocketValentina Straniero, Victor Sebastián-Pérez, Lorenzo Suigo, William Margolin, Andrea Casiraghi, Martina Hrast, Carlo Zanotto, Irena Zdovc, Antonia Radaelli, Ermanno Valoti, 2021, original scientific article Keywords: gram positive-dependent diseases, antibiotic-resistance, MSSA, MRSA, Bacillus subtilis, FtsZ, Z ring, FtsZ inhibition, MIC, pharmacology, chemistry, anti-bacterial agents, methicillin-resistant Staphylococcus aureus, drug resistance, microbiology, benzamides, bacterial proteins Full text (file, 5,49 MB) This document has more files! More... |
14. Screening of big pharma’s library against various in-house biological targetsDamijan Knez, Stanislav Gobec, Martina Hrast, 2022, original scientific article Keywords: Merck Mini Library, screening, MurA, MurC, human MAO-A/B, human BChE, murine AchE Full text (file, 8,55 MB) This document has more files! More... |
15. A fine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIsAnja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: antibacterials, drug discovery, DNA gyrase inhibitors, topoisomerase IV inhibitors, intercalators, novel bacterial topoisomerase inhibitors, topoisomerase II inhibitors, intercalating agents Full text (file, 6,80 MB) This document has more files! More... |
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17. Uvedba bioizosternih zamenjav za fenilno skupino na mestu 1 pri 1,2,3,4-tetrahidropirolo[1,2-a]pirazinskem tipu zaviralcev InhAJanja Ahej, 2018, master's thesis Keywords: mikrobakterijska celična stena, mikolna kislina, zaviralci InhA, sinteza spojin Full text (file, 2,70 MB) |
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19. The structural features of novel bacterial topoisomerase inhibitors that define their activity on topoisomerase IVMaja Kokot, Marko Anderluh, Martina Hrast, Nikola Minovski, 2022, review article Keywords: genetics, inhibition, bacteria, phenyls Full text (file, 5,07 MB) This document has more files! More... |
20. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warheadKatarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György Keserü M., Stanislav Gobec, 2022, original scientific article Keywords: antibacterial agents, UDP-N-acetylglucosamine enolpyruvyl transferase, thiol reactivity Full text (file, 4,05 MB) This document has more files! More... |