11. Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader designRobert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann, Christian Steinebach, 2023, original scientific article Keywords: the Petasis borono-Mannich reaction, Strecker synthesis, CRBN ligands
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12. Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteinsYuen Lam Dora Ng, Aleša Bricelj, Jacqueline A. Jansen, Arunima Murgai, Kirsten Peter, Katherine A. Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Izidor Sosič, 2023, original scientific article Keywords: antagonists, degradation, ligands, mixtures, peptides, proteins, pharmaceutical chemistry Full text (file, 5,93 MB) This document has more files! More... |
13. 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseasesDamijan Knez, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Stanislav Gobec, José Marco-Contelles, 2023, original scientific article Keywords: quinolylnitrone, butyrylcholinesterase, monoamine oxidase B, Alzheimer's disease, multifunctional ligands, 6-hydroxydopamine model, passive avoidance task, novel object recognition Full text (file, 3,96 MB) This document has more files! More... |
14. All-atom simulations reveal the intricacies of signal transduction upon binding of the HLA-E ligand to the transmembrane inhibitory CD94/NKG2A receptorMartin Ljubič, Eva Prašnikar, Andrej Perdih, Jure Borišek, 2023, original scientific article Keywords: cells, ligands, membranes, peptides, proteins, receptors Full text (file, 6,74 MB) This document has more files! More... |
15. CAT-SiteŽan Hafner Petrovski, Barbara Hribar-Lee, Zoran Bosnić, 2022, original scientific article Keywords: protein binding site prediction, ligands, molecular docking, machine learning, convolutional neural network Full text (file, 10,33 MB) This document has more files! More... |
16. Small-Molecule Galectin Ligands: Structure-Based Optimisation of Affinity and SelectivitySjors Van Klaveren, 2024, doctoral dissertation Keywords: Galectins, ligands, inhibitors, drug discovery, molecular dynamics simulations, virtual screening, docking studies, structure-activity relationship, X-ray crystallography. Full text (file, 20,83 MB) |