Challenges of deciphering gastric cancer heterogeneity
Hudler, Petra (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://dx.doi.org/10.3748/wjg.v21.i37.10510 Novo okno

Gastric cancer is in decline in most developed countries; however, it still accounts for a notable fraction of global mortality and morbidity related to cancer. High-throughput methods are rapidly changing our view and understanding of the molecular basis of gastric carcinogenesis. Today, it is widely accepted that the molecular complexity and heterogeneity, both inter- and intra-tumour, of gastric adenocarcinomas present significant obstacles in elucidating specific biomarkers for early detection of the disease. Although genome-wide sequencing and gene expression studies have revealed the intricate nature of the molecular changes that occur in tumour landscapes, the collected data and results are complex and sometimes contradictory. Several aberrant molecules have already been tested in clinical trials, although their diagnostic and prognostic utilities have not been confirmed thus far. The gold standard for the detection of sporadic gastric cancer is still the gastric endoscopy, which is considered invasive. In addition, genome-wide association studies have confirmed that genetic variations are important contributors to increased cancer risk and could participate in the initiation of malignant transformation. This hypothesis could in part explain the late onset of sporadic gastric cancers. The elaborate interplay of polymorphic low penetrance genes and lifestyle and environmental risk factors requires additional research to decipher their relative impacts on tumorigenesis. The purpose of this article is to present details of the molecular heterogeneity of sporadic gastric cancers at the DNA, RNA, and proteome levels and to discuss issues relevant to the translation of basic research data to clinically valuable tools. The focus of this work is the identification of relevant molecular changes that could be detected non-invasively.

Jezik:Angleški jezik
Ključne besede:adenocarcinoma, biological marker, DNA methylation
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2015
Št. strani:str. 10510-10527
Številčenje:Vol. 21, iss. 37
ISSN pri članku:1007-9327
DOI:10.3748/wjg.v21.i37.10510 Povezava se odpre v novem oknu
COBISS.SI-ID:32232921 Povezava se odpre v novem oknu
Število ogledov:700
Število prenosov:341
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:World Journal of Gastroenterology
Skrajšan naslov:World J. Gastroenterol.
Založnik:WJC Press
COBISS.SI-ID:21352921 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:adenokarcinom, biološki označevalci, metilacija DNK

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