Neurotoxicity of perineural vs intraneural-extrafascicular injection of liposomal bupivacaine in the porcine model of sciatic nerve block
Seliškar, Alenka (Author), Stopar Pintarič, Tatjana (Author), Cvetko, Erika (Author), Miš, Katarina (Author), Plavec, Tanja (Author), Damjanovska, Marija (Author), Hadžić, Admir (Author), Vuckovic Hasanbegovic, I. (Author)

URLURL - Presentation file, Visit http://dx.doi.org/10.1111/anae.13189 This link opens in a new window

Liposomal bupivacaine is a prolonged-release local anaesthetic, the neurotoxicity of which has not yet been determined. We used quantitative histomorphometric and immunohistochemical analyses to evaluate the neurotoxic effect of liposomal bupivacaine after perineural and intraneural (extrafascicular) injection of the sciatic nerve in pigs. In this double-blind prospective randomised trial, 4 ml liposomal bupivacaine 1.3% was injected either perineurally (n = 5) or intraneurally extrafascicularly (n = 5). Intraneural%extrafascicular injection of saline (n = 5) was used as a control. After emergence from anaesthesia, neurological examinations were conducted over two weeks. After harvesting the sciatic nerves, no changes in nerve fibre density or myelin width indicative of nerve injury were observed in any of the groups. Intraneural injections resulted in longer sensory blockade than perineural (p < 0.003) without persistent motor or sensory deficit. Sciatic nerve block with liposomal bupivacaine in pigs did not result in histological evidence of nerve injury.

Keywords:bupivacaine, sciatic nerve block, neurotoxicity
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Number of pages:str. 1418-1426
Numbering:Vol. 70, iss. 12
ISSN on article:0003-2409
DOI:10.1111/anae.13189 Link is opened in a new window
COBISS.SI-ID:32164313 Link is opened in a new window
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Record is a part of a journal

Shortened title:Anaesthesia
Publisher:Published for the Association of Anaesthetists of Great Britain and Ireland by Academic Press and Grune & Stratton
COBISS.SI-ID:5084935 This link opens in a new window

Secondary language

Keywords:bupivakain, blok ishiadičnega živca, nevrotoksičnost

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