izpis_h1_title_alt

Aberrant methylation patterns in cancer : a clinical view
Hudler, Petra (Avtor), Videtič Paska, Alja (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://dx.doi.org/10.11613/BM.2015.017 Novo okno

Izvleček
Epigenetic mechanisms, such as DNA methylation, DNA hydroxymethylation, post-translational modifications (PTMs) of histone proteins affecting nucleosome remodelling, and regulation by small and large non-coding RNAs (ncRNAs) work in concert with cis and trans acting elements to drive appropriate gene expression. Advances in detection methods and development of dedicated platforms and methylation arrays resulted in an explo - sion of information on aberrantly methylated sequences linking deviations in epigenetic landscape with the initiation and progression of complex diseases. Here, we consider how DNA methylation changes in malignancies, such as breast, pancreatic, colorectal, and gastric cancer could be explo - ited for the purpose of developing specific diagnostic tools. DNA methylation changes can be applicable as biomarkers for detection of malignant disease in easily accessible tissues. Methylation signatures are already proving to be an important marker for determination of drug sensitivity. Even more, promoter methylation patterns of some genes, such as MGMT, SHOX2 , and SEPT9 , have already been translated into commercial clinical assays aiding in patient assessment as adjunct diagnostic tools. In conclusion, the changes in DNA methylation patterns in tumour cells are slowly gaining entrance into routine diagnostic tests as promising biomarkers and as potential therapeutic targets.

Jezik:Angleški jezik
Ključne besede:biomarkers, molecular diagnostics, epigenetics
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2015
Št. strani:str. 161-176
Številčenje:Vol. 25, no. 2
UDK:577
ISSN pri članku:1330-0962
DOI:10.11613/BM.2015.017 Povezava se odpre v novem oknu
COBISS.SI-ID:32016857 Povezava se odpre v novem oknu
Število ogledov:605
Število prenosov:238
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Biochemia medica
Skrajšan naslov:Biochem. med.
Založnik:Hrvatsko društvo medicinskih biokemičara
ISSN:1330-0962
COBISS.SI-ID:3502345 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:biomarkerji, molekularna diagnostika, epigenetika

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