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Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer
Serša, Gregor (Avtor), Čemažar, Maja (Avtor), Teissie, Justin (Avtor), Miklavčič, Damijan (Avtor), Kamenšek, Urška (Avtor), Signori, Emanuella (Avtor), Marshall, Guillermo (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://dx.doi.org/10.1007/s00262-015-1724-2 Povezava se odpre v novem oknu

Izvleček
Electroporation is a platform technology for drug and gene delivery. When applied to cell in vitro or tissues in vivo, it leads to an increase in membrane permeability for molecules which otherwise cannot enter the cell (e.g., siRNA, plasmid DNA, and some chemotherapeutic drugs). The therapeutic effectiveness of delivered chemotherapeutics or nucleic acids depends greatly on their successful and efficient delivery to the target tissue. Therefore, the understanding of different principles of drug and gene delivery is necessary and needs to be taken into account according to the specificity of their delivery to tumors and/or normal tissues. Based on the current knowledge, electrochemotherapy (a combination of drug and electric pulses) is used for tumor treatment and has shown great potential. Its local effectiveness is up to 80 % of local tumor control, however, without noticeable effect on metastases. In an attempt to increase systemic antitumor effectiveness of electrochemotherapy, electrotransfer of genes with immunomodulatory effect (immunogene electrotransfer) could be used as adjuvant treatment. Since electrochemotherapy can induce immunogenic cell death, adjuvant immunogene electrotransfer to peritumoral tissue could lead to locoregional effect as well as the abscopal effect on distant untreated metastases. Therefore, we propose a combination of electrochemotherapy with peritumoral IL-12 electrotransfer, as a proof of principle, using electrochemotherapy boosted with immunogene electrotransfer as in situ vaccination for successful tumor treatment.

Jezik:Angleški jezik
Ključne besede:electroporation, electrochemotherapy, gene electrotransfer, vaccination
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FE - Fakulteta za elektrotehniko
Leto izida:2015
Št. strani:str. 1315-1327
Številčenje:Vol. 64, no. 10
UDK:602.6/.7
ISSN pri članku:0340-7004
DOI:10.1007/s00262-015-1724-2 Povezava se odpre v novem oknu
COBISS.SI-ID:2044027 Povezava se odpre v novem oknu
Število ogledov:413
Število prenosov:173
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Cancer immunology and immunotherapy
Skrajšan naslov:Cancer Immunol Immunother
Založnik:Springer International
ISSN:0340-7004
COBISS.SI-ID:5815303 Povezava se odpre v novem oknu

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Jezik:Slovenski jezik
Ključne besede:elektroporacija, elektrokemoterapija, elektrogenska terapija, cepljenje

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