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Determination of solubility parameters of ibuprofen and ibuprofen lysinate
Kitak, Teja (Avtor), Planinšek, Odon (Avtor), Šibanc, Rok (Avtor), Srčič, Stanko (Avtor), Dumičić, Aleksandra (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.mdpi.com/1420-3049/20/12/19777 Povezava se odpre v novem oknu

Izvleček
In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansenʼs approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansenʼs approach it was [gamma]t=31.15 MPa0.5 and with IGC it was [gamma]t = 35.17 MPa0.5. However, the values of partial solubility parameters, i.e., [gamma]d, [gamma]p and [gammah, differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents.

Jezik:Angleški jezik
Ključne besede:Hansenʼs solubility parameters, extended Hansenʼs approach, inverse gas chromatography, ibuprofen, ibuprofen lysinate
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2015
Št. strani:str. 21549-21568
Številčenje:Vol. 20, iss. 12
UDK:615.011
ISSN pri članku:1420-3049
DOI:10.3390/molecules201219777 Povezava se odpre v novem oknu
COBISS.SI-ID:3983985 Povezava se odpre v novem oknu
Število ogledov:930
Število prenosov:1107
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:Springer, Molecular Diversity Preservation International
ISSN:1420-3049
COBISS.SI-ID:18462981 Povezava se odpre v novem oknu

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