Gamma-enolase : a well known tumour marker, with a less-known role in cancer
Vižin, Tjaša (Author), Kos, Janko (Author)

URLURL - Presentation file, Visit http://www.degruyter.com/view/j/raon.2015.49.issue-3/raon-2015-0035/raon-2015-0035.xml?format=INT This link opens in a new window

Gamma-enolase, known also as neuron-specific enolase (NSE), is an enzyme of the glycolytic pathway, which is expressed predominantly in neurons and cells of the neuroendocrine system. As a tumour marker it is used in diagnosis and prognosis of cancer; however, the mechanisms enrolling it in malignant progression remain elusive. As a cytoplasmic enzyme gamma-enolase is involved in increased aerobic glycolysis, the main source of energy in cancer cells, supporting cell proliferation. However, different cellular localisation at pathophysiological conditions, proposes other cellular engagements. The C-terminal part of the molecule, which is not related to glycolytic pathway, was shown to promote survival of neuronal cells by regulating neuronal growth factor receptor dependent signalling pathways, resulting also in extensive actin cytoskeleton remodelling. This additional function could be important also in cancer cells either to protect cells from stressful conditions and therapeutic agents or to promote tumour cell migration and invasion. Gamma-enolase might therefore have a multifunctional role in cancer progression: it supports increased tumour cell metabolic demands, protects tumour cells from stressful conditions and promotes their invasion and migration.

Keywords:gamma-enolase, cancer, glycolysis, cell survival, tumour marker
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 217-226
Numbering:Vol. 49, no. 3
ISSN on article:1318-2099
DOI:10.515/raon-2015-0035 Link is opened in a new window
COBISS.SI-ID:3908721 Link is opened in a new window
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
COBISS.SI-ID:32649472 This link opens in a new window

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