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Symptoms and signs of ocular surface disease related to topical medication in patients with glaucoma
Strojan Fležar, Margareta (Avtor), Cvenkel, Barbara (Avtor), Štunf, Špela (Avtor), Srebotnik-Kirbiš, Irena (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399518/pdf/opth-9-625.pdf Povezava se odpre v novem oknu

Izvleček
Purpose: The aim of this study was to assess signs and symptoms of ocular surface disease (OSD) and the cytomorphological changes of ocular surface in glaucoma patients using preserved antiglaucoma drops. Methods: In this cross-sectional study, 109 participants (79 patients with topical medication and 30 untreated controls) completed the Ocular Surface Diseases Index (OSDI) questionnaire and underwent an ophthalmic examination, including Schirmer test, tear film breakup time (TBUT), and fluorescein staining. Conjunctival specimens were collected by impression cytology and analyzed by light microscopy using Nelson's grading scheme (grades 0-3). This classification is based on the nucleus-to-cytoplasm ratios of epithelial cells and the numbers of goblet cells, with grade 2 considered abnormal. Results: The medication group had significantly shorter TBUT (median [interquartile range]: 6.0 seconds [5.0-8.0 seconds] vs 9.5 seconds [6.0-12.3 seconds]; P>0.03), greater fluorescein staining (1.0 [0.75-1.25] vs 0 [0-0.25]; P<0.001), and higher impression cytology grade than the control group (median [range]: 1.0 [1:2 to 1:6] vs 0.6 [1:2 to 1:4]; P<0.001). The increas - ing number of drops instilled per day was associated with an increase in fluorescein staining (Spearman's rho r = 0.475; P<0.001) and shorter TBUT ( r =- 0.278; P = 0.014). The OSDI did not discriminate between the two groups. Conclusion: Clinical tests and impression cytology showed ocular surface damage in patients using preserved antiglaucoma medications. However, there was no statistically and clinically significant difference in symptoms measured by OSDI score between the medication and control groups.

Jezik:Angleški jezik
Ključne besede:ocular disease, dry eye, glaucoma
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2015
Št. strani:str. 625-631
Številčenje:Vol. 9
UDK:617.7
ISSN pri članku:1177-5483
DOI:10.2147/OPTH.S81247 Povezava se odpre v novem oknu
COBISS.SI-ID:32508633 Povezava se odpre v novem oknu
Število ogledov:773
Število prenosov:212
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
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Gradivo je del revije

Naslov:Clinical ophthalmology
Skrajšan naslov:Clin. ophthalmol.
Založnik:Dove Medical Press
ISSN:1177-5483
COBISS.SI-ID:523033881 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Neznan jezik
Ključne besede:očesne bolezni, suhe oči, glavkom

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