Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases
Ribarič, Samo (Author), Milisav, Irina (Author), Šuput, Dušan (Author)

URLURL - Presentation file, Visit http://www.mdpi.com/1420-3049/20/12/19865/htm This link opens in a new window

Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.

Keywords:Alzheimer's disease, autophagy, Parkinson's disease
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Number of pages:str. 22718-22756
Numbering:Vol. 20, no. 12
ISSN on article:1420-3049
DOI:10.3390/molecules201219865 Link is opened in a new window
COBISS.SI-ID:32400601 Link is opened in a new window
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Record is a part of a journal

Shortened title:Molecules
Publisher:Springer, Molecular Diversity Preservation International
COBISS.SI-ID:18462981 This link opens in a new window

Secondary language

Keywords:Alzheimerjeva bolezen, avtofagija, Parkinsonova bolezen

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