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Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases
Ribarič, Samo (Avtor), Milisav, Irina (Avtor), Šuput, Dušan (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.mdpi.com/1420-3049/20/12/19865/htm Povezava se odpre v novem oknu

Izvleček
Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.

Jezik:Angleški jezik
Ključne besede:Alzheimer's disease, autophagy, Parkinson's disease
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2015
Št. strani:str. 22718-22756
Številčenje:Vol. 20, no. 12
UDK:616-092
ISSN pri članku:1420-3049
DOI:10.3390/molecules201219865 Povezava se odpre v novem oknu
COBISS.SI-ID:32400601 Povezava se odpre v novem oknu
Število ogledov:1055
Število prenosov:331
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:Springer, Molecular Diversity Preservation International
ISSN:1420-3049
COBISS.SI-ID:18462981 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Neznan jezik
Ključne besede:Alzheimerjeva bolezen, avtofagija, Parkinsonova bolezen

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