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Developmental myosins : expression patterns and functional significance
Smerdu, Vika (Avtor), Schiaffino, Stefano (Avtor), Rossi, Alberto C. (Avtor), Leinwand, Leslie A. (Avtor), Reggiani, Carlo (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.skeletalmusclejournal.com/content/5/1/22 Povezava se odpre v novem oknu

Izvleček
Developing skeletal muscles express unique myosin isoforms, including embryonic and neonatal myosin heavy chains, coded by the myosin heavy chain 3 (MYH3) and MYH8 genes, respectively, and myosin light chain 1 embryonic/atrial, encoded by the myosin light chain 4 (MYL4) gene. These myosin isoforms are transiently expressed during embryonic and fetal development and disappear shortly after birth when adult fast and slow myosins become prevalent. However, developmental myosins persist throughout adult stages in specialized muscles, such as the extraocular and jaw-closing muscles, and in the intrafusal fibers of the muscle spindles. These myosins are re-expressed during muscle regeneration and provide a specific marker of regenerating fibers in the pathologic skeletal muscle. Mutations in MYH3 or MYH8 are responsible for distal arthrogryposis syndromes, characterized by congenital joint contractures and orofacial dysmorphisms, supporting the importance of muscle contractile activity and body movements in joint development and in shaping the form of the face during fetal development. The biochemical and biophysical properties of developmental myosins have only partially been defined, and their functional significance is not yet clear. One possibility is that these myosins are specialized in contracting against low loads, and thus, they may be adapted to the prenatal environment, when fetal muscles contract against a very low load compared to postnatal muscles.

Jezik:Angleški jezik
Ključne besede:muscle development, muscle regeneration, myosin
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2015
Št. strani:str. 1-14
Številčenje:Vol. 5
UDK:611
ISSN pri članku:2044-5040
DOI:10.1186/s13395-015-0046-6 Povezava se odpre v novem oknu
COBISS.SI-ID:32265177 Povezava se odpre v novem oknu
Število ogledov:341
Število prenosov:166
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Skeletal muscle
Skrajšan naslov:Skelet. muscle
Založnik:BioMed Central
ISSN:2044-5040
COBISS.SI-ID:518211097 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Neznan jezik
Ključne besede:razvitost mišic, regeneracija mišic, miozin

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