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Effects of flavonoids from food and dietary supplements on glial and glioblastoma multiforme cells
Komel, Radovan (Avtor), Vidak, Marko (Avtor), Rozman, Damjana (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.mdpi.com/1420-3049/20/10/19406 Novo okno

Izvleček
Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed.

Jezik:Angleški jezik
Ključne besede:food, dietary supplements, flavonoids
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2015
Št. strani:str. 19406-19432
Številčenje:Vol. 20, no. 10
UDK:577
ISSN pri članku:1420-3049
DOI:10.3390/molecules201019406 Povezava se odpre v novem oknu
COBISS.SI-ID:32258265 Povezava se odpre v novem oknu
Število ogledov:596
Število prenosov:169
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:Springer, Molecular Diversity Preservation International
ISSN:1420-3049
COBISS.SI-ID:18462981 Novo okno

Sekundarni jezik

Jezik:Neznan jezik
Ključne besede:hrana, prehranska dopolnila, flavonoidi

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