Effects of flavonoids from food and dietary supplements on glial and glioblastoma multiforme cells
Komel, Radovan (Author), Vidak, Marko (Author), Rozman, Damjana (Author)

URLURL - Presentation file, Visit http://www.mdpi.com/1420-3049/20/10/19406 New window

Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed.

Keywords:food, dietary supplements, flavonoids
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Number of pages:str. 19406-19432
Numbering:Vol. 20, no. 10
ISSN on article:1420-3049
DOI:10.3390/molecules201019406 Link is opened in a new window
COBISS.SI-ID:32258265 Link is opened in a new window
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Shortened title:Molecules
Publisher:Springer, Molecular Diversity Preservation International
COBISS.SI-ID:18462981 New window

Secondary language

Keywords:hrana, prehranska dopolnila, flavonoidi

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