Redox control of protein degradation
Ribarič, Samo (Author), Milisav, Irina (Author), Pajares, Marta (Author), Jiménez-Moreno, Natalia (Author), Dias, Irundika H. K. (Author), Debelec, Bilge (Author), Vucetic, Milica (Author), Fladmark, Kari E. (Author), Basaga, Huveyda (Author), Cuadrado, Antonio (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/article/pii/S2213231715000750 This link opens in a new window

Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathies.

Keywords:protein oxidation, proteolysis, autophagy
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Number of pages:str. 409-420
Numbering:Vol. 6
ISSN on article:2314-6141
DOI:10.1016/j.redox.2015.07.003 Link is opened in a new window
COBISS.SI-ID:32219097 Link is opened in a new window
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Record is a part of a journal

Title:BioMed research international
Shortened title:Biomed Res Int
Publisher:Hindawi Pub. Co.
COBISS.SI-ID:30624729 This link opens in a new window

Secondary language

Keywords:oksidacija proteinov, proteoliza, avtofagija

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