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Serum survivin levels and outcome of chemotherapy in patients with malignant mesothelioma
Kovač, Viljem (Avtor), Dolžan, Vita (Avtor), Dodič-Fikfak, Metoda (Avtor), Goričar, Katja (Avtor), Franko, Alenka (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.hindawi.com/journals/dm/2015/316739/ Povezava se odpre v novem oknu

Izvleček
Background. Survivin is an inhibitor of apoptosis protein involved in the regulation of cell proliferation that could be used as a marker for cancer diagnosis or prognosis.Our aimwas to evaluatewhether serumsurvivin levels influence the outcome of cisplatinbased chemotherapy in patients with malignant mesothelioma (MM). Methods. Serum survivin levels were determined using human survivin enzyme-linked immunosorbent assay in 78MMpatients before chemotherapy, after chemotherapy, and at disease progression. The influence on tumor response and survival was evaluated using nonparametric tests and Cox regression. Results. A median serum survivin level at diagnosis was 4.1 (0%217.5) pg/mL. Patients with a progressive disease had significantly higher survivin levels before chemotherapy (p = 0.041). A median serum survivin level after chemotherapy was 73.1 (0%346.2) pg/mL. If survivin levels increased after chemotherapy, patients had, conversely, better response (p = 0.001, OR = 5.40, 95% CI = 1.98%14.72). Unexpectedly, patients with increased survivin levels after chemotherapy also had longer progression-free (p < 0.001, HR = 0.33, 95% CI = 0.20%0.57) and overall survival (p = 0.001, HR = 0.29, 95% CI = 0.14%0.58). Conclusions. These results suggest that serum survivin levels before and during chemotherapy could serve as a biomarker predicting MM treatment response.

Jezik:Angleški jezik
Ključne besede:malignant mesothelioma, chemotherapy, serum survivin levels
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2015
Št. strani:str. 1-8
Številčenje:Vol. 2015
UDK:616-006
ISSN pri članku:1875-8630
DOI:10.1155/2015/316739 Povezava se odpre v novem oknu
COBISS.SI-ID:32176857 Povezava se odpre v novem oknu
Število ogledov:605
Število prenosov:252
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Disease markers
Založnik:IOS Press
ISSN:1875-8630
COBISS.SI-ID:516120089 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Neznan jezik
Ključne besede:maligni mezoteliom, kemoterapija, serumska raven survivina

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