Polymorphisms of the Peroxisome Proliferator-Activated Receptor-[gamma] (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus

Nikolajević-Starčević, Jovana (author), Petrovič, Danijel (author), Kruzliak, Peter (author), Haley, Andreana P (author), Gaspar, Ludovit (author)

The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1 (PGC-1alpha) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population. The second aim was to find an association of both polymorphisms with T2DM. Methods: Two exonic SNPs of both genes rs1801282 of the PPAR-gamma gene and rs8192673 of the PGC-1alpha gene) were genotyped in 881 unrelated Slovene subjects (Caucasians) with T2DM and in 348 subjects without T2DM (control subjects). Results: Female homozygotes with the CC genotype of the rs8192673 had higher waist circumference in comparison with subjects with other genotypes. Homozygotes (females, males) with wild allele (Pro) of the rs1801282 (Pro12Ala polymorphism) had higher waist circumference in comparison with subjects with other genotypes. In the study, there were no differences in the distributions of the rs8192673 and the rs1801282 genotypes between patients with T2DM and controls. Linear regression analyses for both polymorphisms were performed and demonstrated an independent effect of the rs1801282 of the PPAR-gamma on waist circumference in subjects with T2DM, whereas an independent effect on waist circumference was not demonstrated for the rs8192673 of the PGC-1alpha gene. Conclusions: In a large sample of the Caucasians the rs8192673 of the PGC-1alpha gene and the rs1801282 of the PPAR-gamma gene were associated with waist circumference in subjects with T2DM.

• Language: English
• Keywords: type 2 diabetes mellitus, obesity indexes, polymorphism
• Work type: Not categorized (r6)
• Tipology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Year: 2015
• Numbering: Vol. 14
• UDC: 616.379
• ISSN on article: 1475-2840
• DOI: 10.1186/s12933-015-0197-0
• COBISS.SI-ID: 31947481
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Record is a part of a journal

• Title: Cardiovascular diabetology
• Shortened title: Cardiovasc Diabetol
• Publisher: BioMed Central
• ISSN: 1475-2840
• COBISS.SI-ID: 2595092

Secondary language

• Language: Unknown
• Keywords: sladkorna bolezen tip 2, indeks telesne mase, polimorfizem