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Influence of 5-HT1A and 5-HTTLPR genetic variants on the schizophrenia symptoms and occurrence of treatment-resistant schizophrenia
Kastelic, Matej (Author), Terzič, Tea (Author), Dolžan, Vita (Author), Kores-Plesničar, Blanka (Author)

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Abstract
This study aimed to explore the influence of two genetic polymorphisms of the 5-hydroxytryptamine 1A receptor (5-HT1A) and solute carrier family 6, member 4 (SLC6A4) genes on the clinical symptoms and treatment resistance in Slovenian patients with schizophrenia. A total of 138 patients with schizophrenia were evaluated using the Positive and Negative Syndrome Scale, Brief Psychiatric Rating Scale, Clinical Global Impression, and Global Assessment of Functioning. Based on the selected criteria, 94 patients were included in the treatment-responsive and 44 in the treatment-resistant group. All subjects and 94 controls were genotyped for the 5-HT1A rs6295 and 5-HTTLPR polymorphisms. There were no statistically significant differences in the frequencies of these polymorphisms between the patients with schizophrenia and the control group and between the treatment-resistant and treatment-responsive group of schizophrenia patients. Polymorphisms rs6295 and 5-HTTLPR had an influence on the Global Assessment of Functioning scale score, while 5-HTTLPR also had an influence on the total score of the negative subscale within the Positive and Negative Syndrome Scale. Although we found no effect on progression toward the treatment-resistant schizophrenia, our data suggest that the rs6295 and 5-HTTLPR polymorphisms can influence some clinical symptoms in schizophrenia.

Language:English
Keywords:antipsychotics, genetic polymorphisms, serotonergic receptor
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Year:2015
Number of pages:str. 453-459
Numbering:Vol. 11, Vol. 11
UDC:616.89
ISSN on article:1178-2021
DOI:10.2147/NDT.S76494 Link is opened in a new window
COBISS.SI-ID:31881689 Link is opened in a new window
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Downloads:271
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Record is a part of a journal

Title:Neuropsychiatric Disease and Treatment
Publisher:Dove Medical Press
ISSN:1178-2021
COBISS.SI-ID:3223572 This link opens in a new window

Secondary language

Language:Unknown
Keywords:antipsihotiki, genetski polimorfizmi, serotoninergični receptor

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