izpis_h1_title_alt

Low nucleotide variability of CYP51A1 in humans : meta-analysis of cholesterol and bile acid synthesis and xenobiotic metabolism pathways
Lewinska, Monika (Author), Prosenc, Uršula (Author), Rozman, Damjana (Author)

URLURL - Presentation file, Visit http://acta.chem-soc.si/60/60-4-875.pdf This link opens in a new window

Abstract
Lanosterol 14-demethylase CYP51 is the most conserved cytochrome P450 (CYP) and is a part of hepatic cholesterolsynthesis. Other liver CYPs contribute to cholesterol detoxification through bile acids or to xenobiotic detoxification(DM). To get novel insights into characteristics of the CYP51A1 locus that was so far not linked to human disorders weperformed a meta-analysis of CYP51A1 gene polymorphisms in comparison to other liver CYPs and other genes of cholesterolsynthesis. Cholesterol linked genes are generally less polymorphic than DM CYPs, with less coding variants,indicating differences in selection pressure between cholesterol and xenobiotic pathways. Among the studied liverCYPs, CYP51A1 has the lowest number of coding variants, and less common variants compared to average for cholesterolsynthesis. We were not able to detect other functional molecules within the CYP51 gene (such as lincRNA or mi-RNA), so we looked into the entire gene locus. We found the AL133568 sequence that overlaps with the CYP51A1 promoterregion. Our hypothesis was that the AL133568 transcript may have a role in regulating CYP51A1 expression, butwe were unable to prove this experimentally. The reason for the low population variability of the human CYP51A1 thusremains uncertain.

Language:English
Keywords:cholesterol, polymorphism, cytochrome P450
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Year:2013
Publisher:Slovenian Chemical Society
Number of pages:str. 875-883
Numbering:Vol. 60, no. 4
UDC:577:547.922
ISSN on article:1318-0207
COBISS.SI-ID:31047129 Link is opened in a new window
Views:643
Downloads:217
Metadata:XML RDF-CHPDL DC-XML DC-RDF
 
Average score:(0 votes)
Your score:Voting is allowed only to logged in users.
:
Share:AddThis
AddThis uses cookies that require your consent. Edit consent...

Record is a part of a journal

Title:Acta chimica slovenica
Shortened title:Acta chim. slov.
Publisher:Slovensko kemijsko društvo, =Slovenian Chemical Society
ISSN:1318-0207
COBISS.SI-ID:14086149 This link opens in a new window

Secondary language

Language:Slovenian
Keywords:holesterol, polimorfizem, citokrom P450, Poissonovo število

Similar documents

Similar works from RUL:
Similar works from other Slovenian collections:

Comments

Leave comment

You have to log in to leave a comment.

Comments (0)
0 - 0 / 0
 
There are no comments!

Back