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Relationship between markers of endothelial dysfunction and inflammation and subclinical atherosclerosis in HIV-infected male patients below 55 years of age
Pirš, Mateja (Avtor), Jug, Borut (Avtor), Eržen, Barbara (Avtor), Šabovič, Mišo (Avtor), Karner, Primož (Avtor), Poljak, Mario (Avtor), Tomažič, Janez (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite https://s3-eu-west-1.amazonaws.com/thejournalhub/10.15570/actaapa.2014.12/actaapa.2014.12.pdf Povezava se odpre v novem oknu

Izvleček
Introduction: Antiretroviral therapy in HIV-infected patients appears to be associated with increased incidence of cardiovascular disease (CVD).The aim of our study was to investigate the differences in markers of inflammation, endothelial dysfunction and prothrombotic state between treated and untreated HIV-infected patients with or without subclinical atherosclerosis. Methods: Eighty-six Slovenian HIV-infected male patients below the age of 55 participated in our study. Levels of high-sensitivity C- reactive protein (hsCRP), vascular cell adhesion molecule 1 (VCAM-1) and plasminogen activator inhibitor 1 (PAI-1) were measured. The presence of subclinical atherosclerosis was determined by measuring carotid intima-media thickness. Results: The level of hsCRP was significantly increased in HIV-infected patients; it was higher in treated than untreated patients. VCAM-1 was significantly increased; it was higher in untreated than treated patients. PAI-1 was significantly increased; there were no differences between untreated and treated patients. Patients with subclinical atherosclerosis had elevated hsCRP; levels of VCAM-1 and PAI-1 were not significantly different. Conclusion: Signs of systemic and vascular inflammation persist in both untreated and treated HIV infected patients. None of the studied markers contributed to improved assessment of subclinical atherosclerosis. The usefulness of such markers in routine clinical evaluation of CVD risk in HIV infected patients remains unclear.

Jezik:Angleški jezik
Ključne besede:HIV infection, endothelial dysfunction, subclinical atherosclerosis
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2014
Založnik:Slovene Welding Society
Št. strani:str. 49-52
Številčenje:Vol. 23, iss. 3
UDK:616.1
ISSN pri članku:1318-4458
COBISS.SI-ID:31603417 Povezava se odpre v novem oknu
Število ogledov:900
Število prenosov:283
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Acta dermatovenerologica Alpina, Panonnica et Adriatica
Skrajšan naslov:Acta dermatovenerolog. Alp. Panon. Adriat.
Založnik:Slovene Welding Society
ISSN:1318-4458
COBISS.SI-ID:31649024 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:okužbe z virusom HIV, endotelijska disfunkcija, subklinična ateroskleroza

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