Mono-ADP-ribosyltransferase as a potential pharmacological drug target in the GLP-1 based therapy of obesity and diabetes mellitus type 2
Bavec, Aljoša (Author)

URLURL - Presentation file, Visit http://www.dlib.si/details/URN:NBN:SI:doc-ZHWSLL59 This link opens in a new window

Glucagon-like peptide-1 (GLP-1) based therapy is well established for treating diabetes mellitus type 2. Moreover, GLP-1 receptor agonists influence weight loss, and have potential for treating obesity. GLP-1 receptor agonists should be administered in low doses, together with drugs that potentiate insulin release, to avoid some minor side effects. We have focused on incretin hormones, especially GLP-1 and its analogues. Here we discuss the effect of the third intracellular loop-derived peptide of GLP-1 receptor on intracellular mono-ADP-ribosyltransferase and its role in regulating the receptor. We suggest that this intracellular mono-ADP-ribosyltransferase could constitute a possible novel pharmacological target in the treatment of diabetes mellitus type 2 and obesity.

Keywords:diabetes mellitus type 2, glucagon, obesity
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Number of pages:str. 237-242
Numbering:Vol. 60, no. 2
ISSN on article:1318-0207
COBISS.SI-ID:30773209 Link is opened in a new window
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Record is a part of a journal

Title:Acta chimica slovenica
Shortened title:Acta chim. slov.
Publisher:Slovensko kemijsko društvo, =Slovenian Chemical Society
COBISS.SI-ID:14086149 This link opens in a new window

Secondary language

Keywords:sladkorna bolezen tip 2, glukagon, debelost

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