The role of extracellular vesicles in phenotypic cancer transformation

Ogorevc, Eva (avtor), Kralj-Iglič, Veronika (avtor), Veranič, Peter (avtor)

Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.

• Jezik: Angleški jezik
• Vrsta gradiva: Delo ni kategorizirano (r6)
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FE - Fakulteta za elektrotehniko
• Leto izida: 2013
• Št. strani: str. 197-205
• Številčenje: Vol. 47, no. 3
• UDK: 576:616-006
• ISSN pri članku: 1318-2099
• DOI: 10.2478/raon-2013-0037
• COBISS.SI-ID: 269123584
• Skupna ocena: (0 glasov)
• Vaša ocena: Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.

Gradivo je del revije

• Naslov: Radiology and oncology
• Skrajšan naslov: Radiol. oncol.
• Založnik: Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
• ISSN: 1318-2099
• COBISS.SI-ID: 32649472

Sekundarni jezik

• Jezik: Slovenski jezik
• Naslov: [Pomen zunajceličnih veziklov v rakasti transformaciji celic]
• Ključne besede: rak (medicina), tumorske celice, mikrovezikli, biologija celice