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The role of extracellular vesicles in phenotypic cancer transformation
Ogorevc, Eva (Author), Kralj-Iglič, Veronika (Author), Veranič, Peter (Author)

URLURL - Presentation file, Visit http://ojs.szd.si/index.php/ro/article/view/1698 This link opens in a new window

Abstract
Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.

Language:English
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:FE - Faculty of Electrical Engineering
Year:2013
Number of pages:str. 197-205
Numbering:Vol. 47, no. 3
UDC:576:616-006
ISSN on article:1318-2099
DOI:10.2478/raon-2013-0037 Link is opened in a new window
COBISS.SI-ID:269123584 Link is opened in a new window
Views:663
Downloads:276
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 This link opens in a new window

Secondary language

Language:Slovenian
Title:[Pomen zunajceličnih veziklov v rakasti transformaciji celic]
Keywords:rak (medicina), tumorske celice, mikrovezikli, biologija celice

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