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The role of extracellular vesicles in phenotypic cancer transformation
Ogorevc, Eva (Avtor), Kralj-Iglič, Veronika (Avtor), Veranič, Peter (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://ojs.szd.si/index.php/ro/article/view/1698 Povezava se odpre v novem oknu

Izvleček
Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.

Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FE - Fakulteta za elektrotehniko
Leto izida:2013
Št. strani:str. 197-205
Številčenje:Vol. 47, no. 3
UDK:576:616-006
ISSN pri članku:1318-2099
DOI:10.2478/raon-2013-0037 Povezava se odpre v novem oknu
COBISS.SI-ID:269123584 Povezava se odpre v novem oknu
Število ogledov:665
Število prenosov:276
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:[Pomen zunajceličnih veziklov v rakasti transformaciji celic]
Ključne besede:rak (medicina), tumorske celice, mikrovezikli, biologija celice

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