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Prevalence of HPV-16 genomic variant carrying a 63-bp duplicated sequence within the E1 gene in Slovenian women
Bogovac, Željka (Avtor), Lunar, Maja M. (Avtor), Kocjan, Boštjan (Avtor), Seme, Katja (Avtor), Jančar, Nina (Avtor), Poljak, Mario (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.dlib.si/details/URN:NBN:SI:DOC-RCYEJDL0 Povezava se odpre v novem oknu

Izvleček
High-risk HPV, particularly HPV-16, is etiologically associated with the development of cervical cancer and its precursor lesions - cervical intraepithelial neoplasia (CIN). However, most precancerous lesions will not progress to cancer. Numerous studies have shown that HPV-16 consists of several genomic variants, which differ in their association with cervical cancer, viral persistence and the frequency of recurrence of cervical disease.Recently, a novel, presumably less pathogenic, HPV-16 E6-T350G genomicvariant has been identified, carrying a 63-bp in-frame insertion in theE1 gene. No data from Slovenian patients have so far been reported for thisspecific HPV-16 variant. In the present study, therefore, a total of 390 HPV-16 positive samples obtained from the same number of women with normal cytology, CIN I, CIN II, CIN III or cervical cancer, were analyzed. The HPV-16E1 insert variant was detected using real-time PCR-amplification of a 146-210-bp fragment of the E1 gene and PCR-sequencing of a 169-bp fragment of the E6 gene. The HPV-16 E1 insert variant was identified in 7/48 (14.6%), 1/21(4.8%), 2/20 (10.0%), 9/131 (6.9%) and 12/170 (7.1%) of women with normal cytology, CIN I, CIN II, CIN III and cervical cancer, respectively. All HPV-16E1 insert variants with an amplifiable E6 gene belonged to the European HPV-16 E6-350G variant group. No statistically significant differences in the prevalence of HPV-16 E1 insert genomic variant in women presenting with normalcytology and those with the different stages of HPV-16-induced disease were found.

Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2011
Št. strani:str. 135-139
Številčenje:Vol. 20, no. 3
UDK:578
ISSN pri članku:1318-4458
COBISS.SI-ID:29396697 Povezava se odpre v novem oknu
Število ogledov:452
Število prenosov:131
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Acta dermatovenerologica Alpina, Panonnica et Adriatica
Skrajšan naslov:Acta dermatovenerolog. Alp. Panon. Adriat.
Založnik:Slovene Welding Society
ISSN:1318-4458
COBISS.SI-ID:31649024 Povezava se odpre v novem oknu

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