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Dihalni test s sečnino - njegovo mesto v diagnostiki
Osredkar, Joško (Avtor)

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Izvleček
Each year many patients visit their physicians complaining of digestive symptoms, most commonly functional dyspepsia (ĆindigestionĆ) or gastroesophageal reflux (ĆheartburnĆ). However, many patients with abdominal discomfort are actually suffering from gastric or duodenal ulcers that are commonly caused by H. pylori and thus are curable. Clearing the infection usually heals the ulcer and prevents relapse, so an accurate diagnosis is important. There are several options for diagnosing H. pylori infectionČ serology to detect antibodies against the bacteriumč endoscopic biopsy for urease testing (H. pylori produce a urease that breaks down urea to ammonia and carbon dioxide)č histology with special stainsč or culture. Unfortunately,these procedures are invasive, expensive and not always accurate. Serological tests require a blood sample and tell only that a patient has been exposed to H. pylori at some time in the past, but not whether the patient is currently infected. Endoscopy and biopsy can detect current infection - the CLO test urease test allows rapid detection of H. pylori in gastric biopsy specimens - but endoscopy and biopsy are unpleasant medical procedures. Recently, noninvasive, sensitive, specific, easy to perform and patientćs well accepted methods had been developed known as urea breath test (UBT). When an infected person swallows a dose of urea labeled with an isotope of carbon - carbon-13 (13C) or carbon-14 (14C) - H. pylori in the gastric mucosa break down the labeled urea to form ammonia and labeled carbon dioxide. The carbon dioxide is absorbed into the bloodstream and excreted via the lungs. The patient then exhales into a device that measures the level of carbon dioxide. The urea breath test is specific for H. pylori (it detects only urease-producing bacteria), it is sensitive (the labeled ureareaches a large area of the stomach and thus reflects total gastric urease activity) and the results can be reproduced. Conclusions. Invasive andnoninvasive diagnostic tests for H. pylori are described. In a more detailed frame UBT is presented, the test which is recomended in certain instances by European Gastroenterologic Society. The UBT should be available for use in the doctorćs office to provide a rapid diagnosis.

Jezik:Slovenski jezik
Ključne besede:prebavila, gastroenterologija, infekcije, bakterije, Helicobacter pylori, diagnostika, dihalni test
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2004
Št. strani:str. 13-17
Številčenje:Letn. 73, št. 1
UDK:616.33-002-07
ISSN pri članku:1318-0347
COBISS.SI-ID:1458033 Povezava se odpre v novem oknu
Število ogledov:1119
Število prenosov:186
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Zdravniški vestnik
Založnik:Slovensko zdravniško društvo
ISSN:1318-0347
COBISS.SI-ID:32893696 Povezava se odpre v novem oknu

Sekundarni jezik

Jezik:Angleški jezik
Naslov:Urea breath test - it's role in diagnostics

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