izpis_h1_title_alt

Genetika in farmakogenetika Gilbertovega sindroma
Ostanek, Barbara (Author)

URLURL - Presentation file, Visit http://www.dlib.si/details/URN:NBN:SI:doc-9VDTEWIM This link opens in a new window

Abstract
Gilbertov sindrom je najpogostejøa dedna motnja v presnovi bilirubina. Blaga nekonjugirana hiperbilirubinemija nastane kot posledica znićane konjugacije bilirubina zaradi polimorfizmov v genu za UDP-glukuronil-transferazo 1A1 (UGT1A1). Dodatno lahko k njej prispeva zmanjøan transport nekonjugiranega bilirubina v hepatocite zaradi polimorfizmov v genu za organski anionski prenaøalec SLCO1B1. Poleg bilirubina so substrati za UGT1A1 in SLCO1B1 tudi øtevilne zdravilne uoeinkovine. Polimorfizmi v obeh genih, ki so prisotni pri bolnikih z Gilbertovim sindromom, imajo zato pomen v individualizaciji zdravljenja. Njihov vpliv na farmakokinetioeni profil zdravilnih uoeinkovin ins tem na njihove terapevtske ali stranske uoeinke je najbolje prouoeen pri zdravljenju z irinotekanom in pravastatinom.

Language:Slovenian
Keywords:hiperbilirubinemija, UGT1A1, SLCO1B1, polimorfizem, toksičnost zdravil
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:FFA - Faculty of Pharmacy
Year:2009
Number of pages:str. 3-7
Numbering:Let. 60, št. 1
UDC:577.2
ISSN on article:0014-8229
COBISS.SI-ID:2539633 Link is opened in a new window
Views:902
Downloads:203
Metadata:XML RDF-CHPDL DC-XML DC-RDF
 
Average score:(0 votes)
Your score:Voting is allowed only to logged in users.
:
Share:AddThis
AddThis uses cookies that require your consent. Edit consent...

Record is a part of a journal

Title:Farmacevtski vestnik
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 This link opens in a new window

Secondary language

Language:English
Title:Genetics and pharmacogenetics of Gilbert's syndrome
Abstract:
Gilbert's syndrome is the most common hereditary disorder of bilirubin metabolism. Mild unconjugated hyperbilirubinemia results from decreased activity of UDP-glucuronosyltransferase 1A1 due to polymorphisms in the UGT1A1encoding gene. Polymorphisms in the gene encoding organic anion transporter SLCO1B1 can reduce the hepatic uptake of unconjugated bilirubin and also contribute to hyperbilirubinemia. Besides bilirubin, several drugs are also substrates for glucuronidation with UGT1A1 or hepatic uptake by SLCO1B1. Polymorphisms in both genes associated with Gilbert's syndrome have therefore important implications for individualised therapy. Their impact on pharmacokinetic profile and therapeutic or side effects has been best described for irinotecan and pravastatin.


Similar documents

Similar works from RUL:
Similar works from other Slovenian collections:

Comments

Leave comment

You have to log in to leave a comment.

Comments (0)
0 - 0 / 0
 
There are no comments!

Back