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DictyExpress : a dictyostelium discoideum gene expression database with an explorative data analysis web-based interface
Rot, Gregor (Avtor), Parikh, Anup (Avtor), Curk, Tomaž (Avtor), Kuspa, Adam (Avtor), Shaulsky, Gad (Avtor), Zupan, Blaž (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.biomedcentral.com/content/pdf/1471-2105-10-265.pdf Novo okno

Izvleček
BACKGROUND. Bioinformatics often leverages on recent advancements in computer science to support biologists in their scientific discovery process. Such efforts include the development of easy-to-use web interfaces to biomedical databases. Recent advancements in interactive web technologies require us to rethink the standard submit-and-wait paradigm, and craft bioinformatics web applications that share analytical and interactive power with their desktop relatives, while retaining simplicity and availability. RESULTS. We have developed dictyExpress, a database that consists of more than 1000 Dictyostelium discoideum gene expression experiments and features a graphical, highly-interactive, explorative web interface. In dictyExpress, the user can select experiments and genes, perform gene clustering, view gene expression profiles across time, view gene co-expression networks, and perform analyses of Gene Ontology term enrichment. Most importantly, these tasks are achieved through web applications whose components are seamlessly interlinked and immediately respond to events triggered by the user, thus providing a powerful explorative data analysis environment. CONCLUSION. dictyExpress is a precursor for a new generation of web-based bioinformatics applications with simple but powerful interactive interfaces that resemble that of the modern desktop. While dictyExpress serves mainly the Dictyostelium research community, it is relatively easy to adapt it to other datasets. We propose that the design ideas behind dictyExpress will influence the development of similar applications for other model organisms.

Jezik:Angleški jezik
Ključne besede:bioinformatika, iskanje zakonitosti v podatkih, vizualizacija, mikromreže cDNA, spletni program
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FRI - Fakulteta za računalništvo in informatiko
Leto izida:2009
Št. strani:str. 1-18
Številčenje:Vol. 10, 10
UDK:575.112:004
ISSN pri članku:1471-2105
COBISS.SI-ID:7219028 Povezava se odpre v novem oknu
Število ogledov:416
Število prenosov:119
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:BMC bioinformatics
Založnik:BioMed Central
ISSN:1471-2105
COBISS.SI-ID:2433556 Novo okno

Sekundarni jezik

Jezik:Neznan jezik
Ključne besede:bioinformatics, data mining, visualization, cDNA microarray, web-based apllication

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