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Conserved developmental transcriptomes in evolutionarily divergent species
Parikh, Anup (Avtor), Miranda, Edward Roshan (Avtor), Katoh-Kurasawa, Mariko (Avtor), Fuller, Danny (Avtor), Rot, Gregor (Avtor), Žagar, Lan (Avtor), Curk, Tomaž (Avtor), Sucgang, Richard (Avtor), Chen, Rui (Avtor), Zupan, Blaž (Avtor), Loomis, William F. (Avtor), Kuspa, Adam (Avtor), Shaulsky, Gad (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://genomebiology.com/2010/11/3/R35 Novo okno

Izvleček
Background. Evolutionarily divergent organisms often share developmental anatomies despite vast differences between their genome sequences. The social amoebae Dictyostelium discoideum and Dictyostelium purpureum have similar developmental morphologies although their genomes are as divergent as those of man and jawed fish. Results. Here we show that the anatomical similarities are accompanied by extensive transcriptome conservation. Using RNA sequencing we compared the abundance and developmental regulation of all the transcripts in the two species. In both species, most genes are developmentally regulated and the greatest expression changes occur during the transition from unicellularity to multicellularity. The developmental regulation of transcription is highly conserved between orthologs in the two species. In addition to timing of expression, the level of mRNA production is also conserved between orthologs and is consistent with the intuitive notion that transcript abundance correlates with the amount of protein required. Furthermore, the conservation of transcriptomes extends to cell-type specific expression. Conclusions. These findings suggest that developmental programs are remarkably conserved at the transcriptome level, considering the great evolutionary distance between the genomes. Moreover, this transcriptional conservation may be responsible for the similar developmental anatomies of Dictyostelium discoideum and Dictyostelium purpureum.

Jezik:Angleški jezik
Ključne besede:evolucijska ohranjenost razvoja, RNA sekvenciranje, Dictyostelium discoideum, Dictyostelium purpureum
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FRI - Fakulteta za računalništvo in informatiko
Leto izida:2010
Št. strani:str. 3-12
Številčenje:Vol. 11, no. 3
UDK:004.9:57
ISSN pri članku:1474-760X
COBISS.SI-ID:7648084 Povezava se odpre v novem oknu
Število ogledov:507
Število prenosov:163
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
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Gradivo je del revije

Naslov:Genome biology
Skrajšan naslov:Genome biol.
Založnik:BioMed Central
ISSN:1474-760X
COBISS.SI-ID:7654228 Novo okno

Sekundarni jezik

Jezik:Neznan jezik
Ključne besede:evolutionarily conserved development, RNA sequencing, Dictyostelium discoideum, Dictyostelium purpureum

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